Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to NO/cGMP and ATP-sensitive K(+) channels pathway activation in mice

European Journal of Pharmacology
Clarice de Carvalho VelosoAndrea de Castro Perez

Abstract

Substances derived from plants play an important role in the development of new analgesic drugs, among them, triterpenoids. The connection between the participation of L-arginine/NO/cGMP pathway and the activation of ATP-sensitive K(+) channels (KATP) has been established on the peripheral antinociception induced by various drugs. The study assessed the involvement of L-arginine/NO/cGMP/KATP pathway in the antinociceptive effect induced by tingenone, from Maytenus imbricata, against the hyperalgesia evoked by prostaglandin E2 (PGE2) in peripheral pathway. The paw pressure test was used, with hyperalgesia induced by intraplantar injection of PGE2 (2 μg). Tingenone (200 µg/paw) administered into the right hind paw induced a local antinociceptive effect, that was antagonized by l-NOArg, nonselective nitric oxide synthase (NOS) inhibitor and by L-NPA, selective neuronal NOS (nNOS) inhibitor. The L-NIO, selective inhibitor of endothelial (eNOS), and the L-NIL, selective inhibitor of inducible (iNOS), did not alter the peripheral antinociceptive effect of the tingenone. The ODQ, selective soluble guanylyl cyclase inhibitor, prevented the antinociceptive effect of tingenone, and zaprinast, inhibitor of the phosphodiesterase that is cy...Continue Reading

References

Sep 21, 1990·European Journal of Pharmacology·I D DurateS H Ferreira
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·G Edwards, A H Weston
May 6, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M GaertnerV Cechinel-Filho
Feb 29, 2000·British Journal of Pharmacology·A R Rodrigues, I D Duarte
Aug 5, 2000·Journal of Pharmacological and Toxicological Methods·M Islas-CadenaV Granados-Soto
Aug 30, 2001·European Journal of Pharmacology·G G Lázaro-IbáñezV Granados-Soto
Nov 28, 2001·The Journal of Biological Chemistry·Sergei D RybalkinJoseph A Beavo
Aug 23, 2002·European Journal of Pharmacology·Daniela Alves, Igor Duarte
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Mario I OrtizGilberto Castañeda-Hernández
Oct 7, 2004·European Journal of Pharmacology·María OcañaJosé Manuel Baeyens
Apr 25, 2006·Pharmacology, Biochemistry, and Behavior·Mario I OrtizVinicio Granados-Soto
Aug 30, 2008·European Journal of Pharmacology·Alfonso Hernández-PachecoTeresa Mixcoatl-Zecuatl
Dec 19, 2009·Journal of Pharmacological Sciences·Thiago Roberto Lima Romero, Igor Dimitri Gama Duarte
Feb 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thiago M CunhaSergio H Ferreira
Aug 31, 2011·Nitric Oxide : Biology and Chemistry·Thiago R L RomeroIgor D G Duarte
Feb 15, 2012·Nitric Oxide : Biology and Chemistry·Thiago R L RomeroIgor D G Duarte
Feb 22, 2012·Journal of Pharmacological Sciences·Thiago Roberto Lima Romero, Igor Dimitri Gama Duarte
Oct 2, 2014·The International Journal of Neuroscience·Giovane S GaldinoAndrea C Perez
Oct 23, 2014·Planta medica·Clarice de Carvalho VelosoAndrea de Castro Perez

❮ Previous
Next ❯

Citations

Feb 2, 2018·Magnetic Resonance in Chemistry : MRC·Rafael C G PereiraLucienir P Duarte
May 17, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ajeet Kumar SinghManjula Vinayak
Mar 17, 2020·BMC Complementary Medicine and Therapies·Tracy Pastrana-QuintosBeatriz Godínez-Chaparro
Sep 24, 2020·Biochemical and Biophysical Research Communications·Francisca Crislândia Oliveira SilvaHélcio Silva Dos Santos
May 4, 2021·British Journal of Pharmacology·Hannes SchmidtAchim Schmidtko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.