Tinidazole as preventive treatment in elective colonic surgery

Scandinavian Journal of Infectious Diseases
S Persson, H Gnarpe

Abstract

Peroperative tinidazole and placebo treatment were compared with respect to incidence of postoperative infections in a double blind investigation on patients admitted for elective bowel surgery. Patients in the tinidazole group had a significantly reduced postoperative infection rate, compared with the placebo group (7.4% and 46%, respectively). Complications in general were fewer in the tinidazole group and costs for antibiotic treatment decreased. All tinidazole-treated patients had clinically effective blood concentrations of the drug at the time of the operation. In contrast with the placebo-treated subjects, the individuals who developed postoperative wound infections from the tinidazole group had no growth of anaerobic bacteria and no antibody response to Bacteroides sp. The use of tinidazole may therefore be recommended for the prevention of postoperative anaerobic infections in patients undergoing bowel surgery.

References

Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·S J Eykyn, I Phillips
Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·G Gillespie, W McNaught
Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·R V Fiddian
Nov 1, 1978·The British Journal of Surgery·O Khan, H H Nixon
Jan 1, 1979·Scandinavian Journal of Infectious Diseases·B ChristenssonB Ursing
Jul 1, 1978·The Journal of Antimicrobial Chemotherapy·J DuboisP Turgeon
Nov 1, 1978·Diseases of the Colon and Rectum·V A DeGennaroM C Veidenheimer
Jan 1, 1976·British Journal of Anaesthesia·J H Darrell, A H Uttley
Oct 1, 1976·Antimicrobial Agents and Chemotherapy·V L Sutter, S M Finegold
Dec 1, 1975·The Surgical Clinics of North America·B Lorber, R M Swenson
May 1, 1976·American Journal of Surgery·C MageeR F Edlich
Jan 1, 1974·Plant Physiology·R W King, J A Zeevaart

Related Concepts

Clinical Trials
Taenia Coli
Double-Blind Method
Nitroimidazoles
Premedication
Tricolam

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.