Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management.

Neuropsychiatric Disease and Treatment
Michele Fornaro, Matteo Martino

Abstract

Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience. A comprehensive review of MEDLINE literature (from January 1990-January 2010) was performed searching for: "tinnitus", major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents. Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies. Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions ...Continue Reading

References

Nov 1, 1978·The Journal of the Acoustical Society of America·D T Kemp
Sep 1, 1992·Nihon Jibiinkoka Gakkai kaiho·S Ueda
Jan 1, 1991·Scandinavian Audiology·U Rosenhall, A K Karlsson
Oct 1, 1988·Journal of Clinical Psychopharmacology·U BustoC A Naranjo
Oct 2, 1986·The New England Journal of Medicine·U BustoK Sykora
Jan 1, 1985·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·J H Hulshof, P Vermeij
Sep 1, 1983·Southern Medical Journal·R N GoldenC H Nau
Nov 1, 1981·Journal of Clinical Psychopharmacology·D L Evans, R N Golden
Jun 1, 1994·British Journal of Audiology·E DaviesI Donaldson
Feb 1, 1993·British Journal of Audiology·P J Jastreboff, J W Hazell
Nov 15, 1995·Biological Psychiatry·F L LeiterT A Stern
Apr 4, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L Shemen
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·D B Menkes, P M Larson
Apr 14, 1999·The Annals of Pharmacotherapy·L M Humma, M P Swims
Dec 28, 1999·American Journal of Otolaryngology·R A Levine
Aug 30, 2000·Hearing Research·R J SalviD Ding
Jan 9, 2001·Southern Medical Journal·R R ReevesJ E Pendarvis
Jan 5, 2002·The Journal of Otolaryngology·N BayarE Belgin
Jul 3, 2002·Molecular and Cellular Neurosciences·Anita C HallPatricia C Salinas
Jul 15, 2003·Otolaryngologic Clinics of North America·Robert A Dobie
Dec 23, 2003·Internal Medicine·Ariyuki HoriKoichi Tomoda
Jan 27, 2004·Journal of Neuroscience Research·S M MulyS J Potashner
Dec 21, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·István Sziklai
Oct 11, 2005·Drug Discovery Today·Jos J Eggermont
Nov 26, 2005·The European Journal of Neuroscience·Matthieu J GuittonJean-Luc Puel
Jan 18, 2006·Journal of Clinical Psychopharmacology·Sigyn ZögerKajsa-Mia Holgers
Mar 4, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Richard S TylerWilliam Noble
Mar 4, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Robert Aaron Levine
May 3, 2006·The Laryngoscope·Carol A Bauer, Thomas J Brozoski
Oct 21, 2006·The Cochrane Database of Systematic Reviews·P BaldoD J McFerran
Nov 16, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·David L WitsellDebara L Tucci
Nov 23, 2006·Auris, Nasus, Larynx·Miguel A Lopez-GonzalezFrancisco Esteban-Ortega
Jan 16, 2007·Journal of the Association for Research in Otolaryngology : JARO·Thomas J BrozoskiCarol A Bauer
Apr 18, 2007·Archives of Otolaryngology--head & Neck Surgery·Jay F PiccirilloEdward Spitznagel

❮ Previous
Next ❯

Citations

Nov 16, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mehmet HabesogluCagatay Oysu
Jan 31, 2012·General Hospital Psychiatry·Hasan BelliCenk Ural
Mar 22, 2014·Korean Journal of Audiology·Chang Gun ChoBo Hae Kim
Jul 18, 2014·Neurorehabilitation and Neural Repair·Mohamed N ThabitMostafa Youssif
Mar 21, 2019·Current Drug Targets·Azam HosseinzadehSaeed Mehrzadi
Oct 7, 2019·Psychiatry Research·Daniela IvansicChristian Dobel

❮ Previous
Next ❯

Software Mentioned

MED
LINE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Otolaryngologic Clinics of North America
R Dobie
Otolaryngologic Clinics of North America
Andrew J Heller
Audiology : Official Organ of the International Society of Audiology
S I ErlandssonA Axelsson
© 2021 Meta ULC. All rights reserved