PMID: 16612523Apr 14, 2006Paper

Tinnitus treatment with acamprosate: double-blind study

Brazilian Journal of Otorhinolaryngology
Andréia Aparecida de Azevedo, Ricardo Rodrigues Figueiredo

Abstract

Nowadays, the treatment of tinnitus is still a great challenge for the otolaryngologists. Many facts remain unknown in its pathophysiology, leading to many different therapies, with irregular results. Acamprosate is a drug used in alcoholism treatment, due to its regulating effects in glutamatergic and GABA neurotransmission, and has never been used before in the treatment of tinnitus To evaluate efficacy and safety of the acamprosate in the treatment of sensorineural tinnitus. Randomized clinical trial. 50 patients with sensorineural tinnitus were divided into two groups: 25 received acamprosate and 25 placebo, for a period of 3 months, in a prospective double-blind study, being analyzed for its efficacy and safety by the subjective score from 1 to 10 given by the patient. We found a high index of success in the relief of tinnitus, about 86.9%. In 47.8% of the cases we found more than 50% relief. The incidence of side effects was low, 12%, all of them mild. Acamprosate, a drug used in the treatment of alcoholism, is a safe and successful alternative for sensorineural tinnitus' treatment.

Citations

Sep 1, 2015·Journal of Neurosurgery·Dirk De RidderSven Vanneste
Oct 16, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Colleen T PleinRichard M Rosenfeld
Jun 11, 2009·Journal of Clinical Neurology·Byung In HanKyoung Sik Shin
Jun 10, 2017·Restorative Neurology and Neuroscience·Wing Ting ToSven Vanneste
Jun 6, 2020·The Annals of Otology, Rhinology, and Laryngology·Mohammad FarhadiSaeid Mahmoudian
Oct 3, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David E TunkelElizabeth J Whamond
Jul 21, 2020·Neural Plasticity·Kunkun WangShan Sun
Jan 23, 2021·Journal of Clinical Neurology·Byung In HanJi Soo Kim
Jan 31, 2012·General Hospital Psychiatry·Hasan BelliCenk Ural

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