TINTIN, at the interface of chromatin, transcription elongation, and mRNA processing

RNA Biology
Wajid BhatJacques Côté

Abstract

Recent work including high-resolution genome-wide analysis uncovered a new trimeric complex involved in transcription elongation, both as an integral part of the NuA4 histone acetyltransferase and as an independent functional entity. The complex is conserved in eukaryotes and is named TINTIN, for Trimer Independent of NuA4 for transcription Interactions with Nucleosomes. This point of view covers the current knowledge regarding TINTIN's function in modulating chromatin structure and influencing transcription elongation in eukaryotes. It also points to several physical and functional links to co-transcriptional processes, including interactions with the mRNA splicing machinery and the nuclear exosome.

References

Jun 16, 2004·Current Opinion in Genetics & Development·Yannick Doyon, Jacques Côté
Sep 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nevan J KroganJack F Greenblatt
Feb 27, 2007·Cell·Bing LiJerry L Workman
Apr 26, 2008·Current Opinion in Cell Biology·Shatakshi PanditXiang-Dong Fu
May 8, 2009·Journal of Cell Science·Søren Lykke-AndersenTorben Heick Jensen
Oct 14, 2009·Molecular and Cellular Biology·Daniel S GinsburgAlan G Hinnebusch
Apr 7, 2010·Annual Review of Biochemistry·Luke A SelthJesper Q Svejstrup
Jan 11, 2011·Cell·Reini F LucoTom Misteli
Mar 3, 2011·Molecular Cell·Nikita AvvakumovJacques Côté
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Humaira GowherGary Felsenfeld
Jul 13, 2012·Genetics·Roy Parker
Sep 1, 2012·Human Molecular Genetics·Seth J BrownYi Xing
Sep 18, 2012·Biochimica Et Biophysica Acta·Michaela Smolle, Jerry L Workman
Oct 3, 2012·Genes & Development·Jing-Ping Hsin, James L Manley
Dec 22, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Michaela SmolleSwaminathan Venkatesh
Feb 12, 2014·Nature Reviews. Genetics·David L Bentley
May 6, 2014·Molecular Cell·Gwendal DujardinAlberto R Kornblihtt
Sep 23, 2014·Nature Structural & Molecular Biology·Jean-François LemayFrançois Bachand
Oct 11, 2014·The Journal of Biological Chemistry·Daniel S GinsburgAlan G Hinnebusch
Dec 3, 2014·Genes & Development·Nova FongDavid L Bentley

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Citations

Oct 30, 2015·Briefings in Functional Genomics·Michael Downey, Kristin Baetz
Mar 11, 2020·Frontiers in Plant Science·Loreto Espinosa-CoresManuel Piñeiro

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Methods Mentioned

BETA
acetylation
gel filtration
RNA-seq

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