Tiotropium + olodaterol shows clinically meaningful improvements in quality of life

Respiratory Medicine
Dave SinghLeif Bjermer

Abstract

Tiotropium + olodaterol improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease (COPD). The OTEMTO 1 and 2 studies investigated the effects of tiotropium + olodaterol on lung function and health-related quality of life compared to placebo in patients with moderate to severe COPD. In these two replicate, double-blind, parallel-group, placebo-controlled trials, patients were randomised to receive tiotropium + olodaterol 5/5 μg, 2.5/5 μg, tiotropium 5 μg or placebo for 12 weeks, via the Respimat(®) inhaler. Primary end points were St George's Respiratory Questionnaire (SGRQ) total score, forced expiratory volume in 1 s (FEV1) area under the curve from 0 to 3 h (AUC0-3) response and trough FEV1 response. In OTEMTO 1 and 2, tiotropium + olodaterol 5/5 μg improved SGRQ total score by 4.89 (95% confidence interval [CI] -6.90, -2.88) and 4.56 (95% CI -6.50, -2.63) units versus placebo (both p < 0.0001), and 2.49 (95% CI -4.47, -0.51; p < 0.05) and 1.72 (95% CI -3.63, 0.19) units versus tiotropium 5 μg. Tiotropium + olodaterol 2.5/5 μg significantly improved SGRQ score compared to placebo. Both doses significantly improved FEV1 AUC0-3 response compared to placebo and tiotropium 5 μg. Tiotro...Continue Reading

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Citations

Jan 23, 2016·The Lancet. Respiratory Medicine·Lies LahousseGuy G Brusselle
Dec 20, 2015·Drugs·Sohita Dhillon
Mar 28, 2016·Respiratory Medicine·Tomohiro TamuraHiroaki Satoh
Feb 20, 2016·Expert Review of Respiratory Medicine·Luigino CalzettaMario Cazzola
May 26, 2016·Expert Review of Respiratory Medicine·Donald BanerjiNicola A Hanania
Sep 2, 2016·American Journal of Respiratory and Critical Care Medicine·Dave SinghFernando J Martinez
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Feb 2, 2019·Expert Opinion on Pharmacotherapy·Paola RoglianiJosuel Ora
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