TIP: A Web Server for Resolving Tumor Immunophenotype Profiling

Cancer Research
Liwen XuXia Li

Abstract

: Systematically tracking the tumor immunophenotype is required to understand the mechanisms of cancer immunity and improve clinical benefit of cancer immunotherapy. However, progress in current research is hindered by the lack of comprehensive immune activity resources and easy-to-use tools for biologists, clinicians, and researchers to conveniently evaluate immune activity during the "cancer-immunity cycle." We developed a user-friendly one-stop shop web tool called TIP to comprehensively resolve tumor immunophenotype. TIP has the capability to rapidly analyze and intuitively visualize the activity of anticancer immunity and the extent of tumor-infiltrating immune cells across the seven-step cancer-immunity cycle. Also, we precalculated the pan-cancer immunophenotype for 11,373 samples from 33 The Cancer Genome Atlas human cancers that allow users to obtain and compare immunophenotype of pan-cancer samples. We expect TIP to be useful in a large number of emerging cancer immunity studies and development of effective immunotherapy biomarkers. TIP is freely available for use at http://biocc.hrbmu.edu.cn/TIP/. SIGNIFICANCE: TIP is a one-stop shop platform that can help biologists, clinicians, and researchers conveniently evaluate...Continue Reading

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Citations

Dec 12, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dong PanChuan-Yuan Li
May 11, 2021·CNS Neuroscience & Therapeutics·Rong-Jun WanXiao-Yuan Mao
Nov 14, 2020·International Immunopharmacology·Jingjing SongLibin Zhu
Jul 3, 2021·Bioengineering·Marxa L FigueiredoTodd S Emrick
Jul 28, 2021·Cancer Immunology, Immunotherapy : CII·Houshi XuMeiqing Lou
Aug 13, 2021·Frontiers in Molecular Biosciences·Dong ZhangQifeng Yang
Sep 8, 2021·Frontiers in Cell and Developmental Biology·Yilin YanBing Shen
Nov 2, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine L ZimmerNiklas K Björkström

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