Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus

The Prostate
M ShiotaS Naito

Abstract

There are currently few effective therapies for castration-resistant prostate cancer (CRPCa). CRPC which is resistant to castration is thought to result from increased activation of the androgen/androgen receptor (AR) signaling pathway, which may be augmented by AR coactivators. Luciferase reporter assay, Western blotting, quantitative real-time polymerase chain reaction, fluorescence microscopy, cell proliferation assay, and flow cytometry for cell-cycle analysis were used to resolve a role of Tip60 regulating AR in PCa cells. Tip60 regulated transcriptions of AR target genes androgen independently. Tip60 knockdown induced translocation of AR into the cytoplasm. Acetylation-mimicking mutations in the nuclear localization signal sequence caused AR protein to mainly localize in the nucleus despite androgen starvation, whereas non-acetylation-mimicking mutations caused AR to mainly localize in the cytoplasm despite androgen stimulation. Tip60 overexpression in castration-resistant LNCaP derivative CxR cells resulted in increases in the acetylated form of AR and AR localization in the nucleus even without androgen. Consequently, Tip60 silencing suppressed the growth of AR-expressing PCa cells by inducing cell-cycle arrest at the G...Continue Reading

References

Jan 1, 1989·Journal of Steroid Biochemistry·A O BrinkmannE Mulder
Jan 10, 1998·The Journal of Biological Chemistry·T Yamamoto, M Horikoshi
Mar 13, 1999·The Journal of Biological Chemistry·N FujimotoC Chang
Jun 11, 1999·The Journal of Biological Chemistry·M E BradyC N Robson
Jul 29, 1999·Human Mutation·B GottliebM Trifiro
Nov 24, 1999·Molecular and Cellular Biology·C L BevanM G Parker
Sep 19, 2000·The Journal of Urology·B J PatelA S Belldegrun
Oct 24, 2001·The Journal of Biological Chemistry·Hiroshi MiyamotoChawnshang Chang
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yu ZhangShuyuan Yeh
Oct 3, 2002·Cancer Letters·Jose D Debes, Donald J Tindall
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary-Ellen TaplinUNKNOWN Cancer and Leukemia Group B Study 9663
Nov 13, 2003·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Jan 2, 2004·Nature Medicine·Charlie D ChenCharles L Sawyers
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yingli SunBrendan D Price
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I Scher, Charles L Sawyers
Dec 26, 2006·Molecular Cell·Stephen M SykesSteven B McMahon
Oct 3, 2007·Cancer Research·Soo-Yeon ParkYoung-Mee Park
Jan 4, 2008·Cancer Research·Masaki ShiotaKimitoshi Kohno
Mar 6, 2008·Journal of Cell Science·Mark L CutressDavid E Neal
May 7, 2008·The Journal of Biological Chemistry·Naoya MiyamotoKimitoshi Kohno

❮ Previous
Next ❯

Citations

Jun 19, 2013·Molecular and Cellular Biology·Ashraf DarAnindya Dutta
Jul 26, 2011·Molecular Cancer·Zhihua JiangBaskaran Rajasekaran
Oct 12, 2012·PloS One·Kelly CoffeyCraig N Robson
Jul 19, 2013·International Journal of Molecular Sciences·Travis van der SteenHaojie Huang
Dec 25, 2015·Journal of Medicinal Chemistry·Roman P SimonManfred Jung
May 10, 2017·International Journal of Molecular Sciences·Simon J Baumgart, Bernard Haendler
Oct 27, 2017·Toxicological Research·Yongkyu Lee
Feb 17, 2019·Journal of Cellular Physiology·Yaping LiDexin Yin
Jan 5, 2014·Cancer Metastasis Reviews·Zoran Culig, Frédéric R Santer
Mar 22, 2014·Molecular Endocrinology·Vineela Kadiyala, Catharine L Smith
Jun 21, 2014·Scientific Reports·Chunxia GaoJames A L Brown
Feb 11, 2015·Oncogene·A FarriaS Y R Dent
Dec 8, 2015·Epigenomics·Gaëlle JudesDominique Bernard-Gallon
Feb 24, 2017·Nature Reviews. Cancer·Jake ShorttJames E Bradner
Sep 16, 2020·International Journal of Molecular Sciences·Kah Ni TanCatalina Carrasco-Pozo
Nov 2, 2019·International Journal of Molecular Sciences·Catalina Carrasco-PozoVicky M Avery
Sep 16, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua W SmithJohn W Erdman
May 6, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jieping HuTing Sun
May 18, 2017·BMC Medicine·Arash NabbiKarl T Riabowol
Feb 9, 2018·Endocrinology·Bharti Jaiswal, Ashish Gupta
Mar 20, 2018·Journal of Applied Genetics·Ahmed H Ghobashi, Maher A Kamel
Sep 14, 2018·The World Journal of Men's Health·Kazutoshi Fujita, Norio Nonomura
Nov 8, 2018·Endocrine-related Cancer·Xi WeiBo Xu
Jan 26, 2016·Pharmacology & Therapeutics·Stephanie KaypeeTapas K Kundu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.