TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling.

Oncology Reports
Yanping PengShili Liu

Abstract

Targeted inhibition of specific toll-like receptor (TLR) pathways may provide an effective strategy to prevent the development of selected gastric malignancies. Tumor necrosis factor (TNF)-α-induced protein 8-like-2 (TIPE2) was identified as a novel negative regulator of TLR signaling. Our previous study identified TIPE2 as an inhibitor of gastric cancer cell growth; it promotes p27 expression, which leads to restored control of the cell cycle and cell division. However, the molecular mechanism by which TIPE2 regulates p27 remains unclear. In the present study, we examined the expression patterns of TIPE2 in serial clinical gastritis tissues as well as gastric cancer, and found a negative correlation between TIPE2 expression and progression of gastritis to gastric cancer. This negative correlation verified the role of TIPE2 in preventing the occurrence and development of gastric cancer, suggesting that TIPE2 may be a potential biomarker for gastric cancer progression. To determine the mechanism employed by TIPE2 in gastric cell carcinogenesis, a TIPE2-expressing plasmid was introduced into gastric cell lines, and microarray and western blot analysis revealed that TIPE2 selectively upregulates the expression of interferon regula...Continue Reading

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Citations

Apr 18, 2019·Expert Opinion on Therapeutic Targets·Jian JiYu-Chen Fan
Mar 14, 2017·Cellular & Molecular Immunology·Jason R GoldsmithYouhai H Chen
Jun 5, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bingqing ShiPeng Gao
Aug 30, 2017·Molecular Medicine Reports·Jieshu JiangWu Zhou
Mar 17, 2021·International Immunopharmacology·Ling-Ge SuoXue-Jiao Qin

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