TIR Domain-Containing Adapter-Inducing Beta Interferon (TRIF) Mediates Immunological Memory against Bacterial Pathogens

Infection and Immunity
Saravana KanagaveluMasayuki Fukata

Abstract

Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure. Here we show a previously undefined mechanism in which innate and adaptive immunity are linked by TIR domain-containing adapter-inducing beta interferon (TRIF) during establishment and reactivation of memory T cells against Gram-negative enteropathogens. Absence of TRIF in macrophages (Mϕs) but not dendritic cells led to a predominant generation of CD4(+) central memory T cells that express IL-17 during enteric bacterial infection in mice. TRIF-dependent type I interferon (IFN) signaling in T cells was essential to Th1 lineage differentiation and reactivation of memory T cells. TRIF activated memory T cells to facilitate local neutrophil influx and enhance bacterial elimination. These results highlight the importance of TRIF as a mediator of the innate and adaptive immune interactions in achieving the protective properties of memory immunity against Gram-negative bacteria and suggest TRIF as a potential therapeutic target.

References

Sep 16, 1998·Clinical and Experimental Immunology·V A KempfI B Autenrieth
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A E MedvedevS N Vogel
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·P YeJ K Kolls
Feb 12, 2002·Nature Immunology·George KassiotisBrigitta Stockinger
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sadahiro KamiyaTakayuki Yoshimoto
Jun 21, 2005·Journal of Cellular and Molecular Medicine·Kenji Oritani, Yuzuru Kanakura
Sep 15, 2005·The Journal of Experimental Medicine·Kyle I HappelJay K Kolls
Feb 28, 2007·Infection and Immunity·Andrea EcheverryBecky Adkins
Sep 28, 2007·Neoplasia : an International Journal for Oncology Research·Chengjiang GaoPaul C Kuo
Dec 7, 2007·Seminars in Immunology·Shean J AujlaJay K Kolls
Apr 3, 2008·The Journal of Clinical Investigation·Beichu GuoGenhong Cheng
Mar 10, 2009·Seminars in Immunology·Alina C Boesteanu, Peter D Katsikis
Apr 1, 2009·PloS One·Salim BouguermouhMarika Sarfati
Jan 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gernot SellgeArmelle Phalipon
Mar 25, 2010·Immunology·Megan K L MacLeodPhilippa Marrack
Oct 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro V VillarinoAbul K Abbas
Jun 15, 2011·Nature Medicine·Kaoru GeddesStephen E Girardin
Nov 30, 2011·The Journal of Experimental Medicine·John SotolongoMasayuki Fukata
May 9, 2012·Frontiers in Immunology·Brandon Feinen, Michael W Russell
Sep 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pushpa PandiyanMichael J Lenardo
Sep 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy J McGeachy, Stephen J McSorley
Apr 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takeshi KawabeNaoto Ishii
Nov 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph H Chewning, Casey T Weaver
Jan 8, 2015·Apoptosis : an International Journal on Programmed Cell Death·Kannan Badri Narayanan, Hyun Ho Park

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Citations

May 2, 2017·Nature Immunology·Thomas UlasDorothee Viemann

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