Tissue and Blood Biomarkers in Lung Cancer: A Review

Advances in Clinical Chemistry
Michael J Duffy, Ken O'Byrne

Abstract

Lung cancer is the most common cause of cancer-related death, worldwide. Historically, lung cancer has been divided into two main histological types: small cell and nonsmall cell (NSC) type with the latter being subdivided into adenocarcinoma, squamous cell type, and large cell type. The treatment of the NSC lung cancer (NSCLC), especially the adenocarcinoma subtype, has been transformed in the last decade by the availability of predictive biomarkers for molecularly targeted therapies. Currently, for patients with advanced adenocarcinomas, testing for sensitizing mutations in epidermal growth factor receptor (EGFR) is mandatory prior to the administration of anti-EGFR inhibitors such as erlotinib, gefitinib, afatinib, or osimertinib. For patients unable to provide tumor tissue, EGFR mutational analysis may be performed on plasma. For predicting response to crizotinib, testing for ALK and ROS1 gene rearrangement is necessary. The presence of ALK rearrangements is also a prerequisite for treatment with ceritinib, alectinib, or brigatinib. For predicting response to single agent pembrolizumab in the first-line treatment of patients with advanced adenocarcinoma or squamous cell NSCLCs, PD-L1 should be measured by an approved assay ...Continue Reading

Citations

Jan 25, 2019·Current Medicinal Chemistry·Weslley Felix de OliveiraMaria Tereza Dos Santos Correia
Jun 13, 2020·Journal of Clinical Medicine·Roberto GasparriLorenzo Spaggiari
Jan 27, 2021·Immunologic Research·Yulin WangLiping Dai
Jan 9, 2021·Oxidative Medicine and Cellular Longevity·Jie LiuGuohan Chen
Apr 4, 2021·Cancers·Mateusz Smolarz, Piotr Widlak
Jun 25, 2021·International Journal of General Medicine·Yunqi BaoDan Wang
Oct 16, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xintong ShenXiaodan Meng
Nov 24, 2021·Molecular Diagnosis & Therapy·Barbara MeloskyFederico Cappuzzo

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