Tissue and blood superoxide dismutase activity and malondialdehyde level in leprosy

Journal of the European Academy of Dermatology and Venereology : JEADV
H Z Abdel-HafezA A Abd-Elghany

Abstract

Oxidative stress (OS) results from an imbalance between free radical generating and scavenging systems. The end product of lipid peroxidation, malondialdehyde (MDA) serves as a marker of cellular damage. Superoxide dismutase (SOD) traps free radicals and acts as a free radical scavenging system. To study OS indices in paucibacillary (PB) and multibacillary (MB) leprosy in tissues and blood. The study group comprised untreated PB patients (n = 14), untreated MB patients (n = 18) and normal human volunteers (n = 20). SOD activity, MDA level and MDA/SOD ratio were estimated in both blood and tissue. Compared with controls, SOD activity in tissues decreased significantly in both PB and MB patients, while SOD activity in erythrocytes decreased significantly only in MB. In addition, MDA levels increased significantly in tissues of both PB and MB patients. Moreover, the mean level of MDA in plasma of MB patients was significantly higher, whereas there was no significant difference in that of PB patients. This study showed significant increase in OS index (MDA/SOD ratio) in tissue of PB and MB patients and in blood of MB patients only, whereas there was no significant difference in OS index in blood of PB patients compared with that in...Continue Reading

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Citations

Mar 19, 2016·PeerJ·Yvelise T Morato-ConceicaoCor J F Fontes
Dec 16, 2011·The American Journal of the Medical Sciences·Khanh vinh quôc Luʼoʼng, Lan Thi Hoàng Nguyên
Jan 4, 2022·Journal of Biomedical Nanotechnology·Yumei QianLingling Shan

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