PMID: 7067187Feb 1, 1982Paper

Tissue and coronary venous pH in ischemic canine myocardium

Clinical Cardiology
S M CobbeP A Poole-Wilson


The relationship between changes in myocardial tissue pH and local coronary venous pH during and after transient occlusion of the left anterior descending artery was investigated in 6 open chested anesthesized dogs. Tissue pH was recorded with a needle pH electrode, and coronary venous pH with a specially designed catheter tip pH electrode. Myocardial tissue pH fell steadily after coronary occlusion, and had fallen by 0.107 +/- 0.043 pH units (mean +/- SD, n = 12, occlusions) after 150 s. On reperfusion there was a further small fall in tissue pH to 0.138 +/- 0.035 units before tissue pH returned to control. In contrast, the fall of coronary venous pH during ischemia was small (0.15 +/- 0.027 after 150 s, n = 12 occlusions). Within 5 s of reperfusion, a large fall in venous pH occurred, reaching a maximum of 0.150 +/- 0.072 at 20-30 s after reperfusion. During ischemia changes in tissue pH are poorly represented by changes in coronary venous pH. The size of early change of venous pH during the reperfusion washout of retained metabolites is a better estimate of the fall of tissue pH. Measurement of metabolites in the coronary sinus of man during the washout after the end of an ischemic intervention such as a trial pacing is supe...Continue Reading


Apr 1, 1976·Journal of Applied Physiology·O H LeBlancW H Stoddard
Mar 1, 1979·The American Journal of Cardiology·A P SelwynG Forse
Jan 1, 1975·The American Journal of Cardiology·W A NeillR P Anderson
Dec 1, 1969·The American Journal of Physiology·A H HendersonE H Sonnenblick
May 1, 1980·Journal of Medical Engineering & Technology·S M Cobbe, P A Poole-Wilson
Aug 1, 1980·Journal of Molecular and Cellular Cardiology·S M Cobbe, P A Poole-Wilson
Nov 1, 1961·The American Journal of Physiology·J D COFFMAN, D E GREGG


Mar 1, 1989·Biological Trace Element Research·H Zwanziger

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