PMID: 61088Oct 1, 1976Paper

Tissue and hepatic subcellular distribution of liposomes containing bleomycin after intravenous administration to patients with neoplasms

Clinical Science and Molecular Medicine
A W SegalT J Peters

Abstract

1. Liposomes containing 111In-labelled bleomycin were injected intravenously into two patients. One patient had a hepatoma and the other had secondary adenocarcinomatous deposits in the liver. 2. The tissue distribution of 111In was determined by whole-body scanning and by measurement of the radioactivity in organs at autopsy. 3. Scans in vivo and post-mortem measurement of radioactivity indicated that liposomes accumulate predominantly in the liver, but that there is no selective uptake of liposomes by the malignant tissue. 4. The subcellular distribution of radioactivity in the liver was measured 90 min after injection by fractionation of percutaneous liver biopsies on sucrose density gradients. 5. Radioactivity within the liver was concentrated in lysosomes. 6. Electron microscopy of tissue obtained before the administration of liposomes revealed particles morphologically indistinguishable from liposomes in hepatoma cells and hepatocytes.

Citations

Jan 1, 1984·Journal of Microencapsulation·P M ShulkinD F Adams
Sep 1, 1982·European Journal of Cancer & Clinical Oncology·K R PatelY E Rahman
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·R Roy, S Kim
Feb 3, 1977·Nature·G Gregoriadis
Aug 8, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francis ManRafael T M de Rosales
Jul 15, 1986·Cancer·A I Freeman, E Mayhew
Jan 1, 1978·Annals of the New York Academy of Sciences·G Gregoriadis

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