PMID: 9551879Apr 29, 1998Paper

Tissue angiotensin II concentration in the heart and kidneys in transgenic Tsukuba hypertensive mice

Blood Pressure
T KaiK Ishikawa

Abstract

Tsukuba hypertensive mice (THM) are transgenic mice carrying both human renin and angiotensinogen genes, and possessing an overexpressing human renin-angiotensin system. The aim of this study is to evaluate the angiotensin II concentration in the heart and kidney in THM. Twenty-week-old male THM and control C57BL/6 mice (C57) were used. Each group consisted of 3 mice. For each mouse, systolic blood pressure, heart to body weight ratio, renal glomerular sclerosis index and angiotensin II concentration in the heart and kidney were measured. Systolic blood pressure of THM was about 40 mmHg higher than that of C57. Heart to body weight ratio and renal glomerular sclerosis index were significantly higher in THM than those in C57. The angiotensin II concentration in THM was about 4 times higher in the heart and about 5 times higher in the kidney compared with that in C57. These results suggest that accelerated tissue angiotensin II production, significant cardiac hypertrophy and renal glomerular sclerosis all occur because of hypertension.

Citations

Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·T KaiK Ishikawa
Aug 21, 2013·Scientific Reports·Ronan AstinGyorgy Szabadkai
Mar 9, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrea HartnerKarl F Hilgers
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lina NordquistA Erik G Persson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.