Tissue-associated cytokine expression in HIV-positive persons with oropharyngeal candidiasis

The Journal of Infectious Diseases
Elizabeth A LillyPaul L Fidel

Abstract

Oropharyngeal candidiasis (OPC), caused by Candida albicans, is the most common infection in human immunodeficiency virus (HIV)-positive persons. Although CD4(+) T cells are considered to be important for host defense against C. albicans at the oral mucosa, a recent immunohistochemical evaluation of T cells in OPC lesions of HIV-positive persons with reduced CD4(+) T cells showed high numbers of CD8(+) T cells. The present study investigated tissue-associated expression of cytokine and chemokine mRNA at the site of infection. Results showed some effects of HIV (primarily increased chemokine mRNA levels) but little effect of blood CD4(+) T cells. In contrast, mRNA for several proinflammatory, T helper, and CD8(+) T cell-associated cytokines and chemokines were increased in subjects with OPC versus those without. These results support the presence of CD8(+) T cells in OPC lesions and suggest evidence for a response against OPC, despite reduced levels of CD4(+) T cells.

Citations

Oct 14, 2008·Expert Reviews in Molecular Medicine·Cristina Cunha Villar, Anna Dongari-Bagtzoglou
Jul 26, 2005·Infection and Immunity·C C VillarA Dongari-Bagtzoglou
Apr 30, 2016·Jundishapur Journal of Microbiology·Seyyed Amin Ayatollahi MousaviAlireza Izadi
Apr 20, 2005·Oral Microbiology and Immunology·E A LillyP L Fidel
Jul 9, 2013·Gerodontology·Siripen Pesee, Teerakul Arpornsuwan
Oct 26, 2005·Journal of Dental Research·A Dongari-Bagtzoglou, P L Fidel
May 5, 2006·Advances in Dental Research·M M CooganL P Samaranayake
Jul 11, 2006·Mycopathologia·E A LillyP L Fidel

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