Tissue characterization using electrical impedance spectroscopy data: a linear algebra approach

Physiological Measurement
Shlomi LauferBoris Rubinsky

Abstract

In this study, we use a new linear algebra manipulation on electrical impedance spectroscopy measurements to provide real-time information regarding the nature of the tissue surrounding the needle in minimal invasive procedures. Using a Comsol Multiphysics three-dimensional model, a phantom based on ex vivo animal tissue and in vivo animal data, we demonstrate how tissue inhomogeneity can be characterized without any previous knowledge of the electrical properties of the different tissues, except that they should not be linearly dependent on a certain frequency range. This method may have applications in needle biopsies, radiation seeds, or minimally invasive surgery and can reduce the number of computer tomography or magnetic resonance imaging images. We conclude by demonstrating how this mathematical approach can be useful in other applications.

References

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Jul 13, 2006·IEEE Transactions on Bio-medical Engineering·Jon F EddBoris Rubinsky
Dec 5, 2006·Bioelectrochemistry·Antoni Ivorra, Boris Rubinsky
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Jan 13, 2009·Physiological Measurement·Håvard KalvøyAudun Stubhaug
May 19, 2009·IEEE Transactions on Bio-medical Engineering·Yuan JiangOlaf Dössel
Aug 18, 2009·The Journal of Urology·Ryan J HalterKeith D Paulsen
Jun 26, 2010·Physiological Measurement·Shlomi LauferStephen B Solomon

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Citations

Jan 15, 2013·IEEE Transactions on Bio-medical Engineering·Alexander Golberg, Martin L Yarmush
Sep 2, 2015·Medical & Biological Engineering & Computing·L G CampanaA L Tosi

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