Tissue content of vitamin D3 and 25-hydroxy vitamin D3 in minipigs after cutaneous synthesis, supplementation and deprivation of vitamin D3

Steroids
Anders BurildJette Jakobsen

Abstract

Information regarding the endogenous storages of vitamin D3 after cutaneous vitamin D synthesis compared to oral vitamin D3 supplementation is sparse. Furthermore it is not known whether vitamin D3 can be stored for later use during periods of shortages of vitamin D3. To investigate the endogenous storages of vitamin D3 two studies were carried out in Göttingen minipigs. In study 1 one group of minipigs (n=2) was daily exposed to UV light corresponding to 10-20 min of midday sun and another group (n=2) of pigs were fed up to 60 μg vitamin D3/day corresponding to 3.7-4.4 μg/kg body weight. Study 1 demonstrated that daily UV-exposure of minipigs stimulated the cutaneous synthesis of vitamin D3 and resulted in increasing serum vitamin D3 and 25-hydroxy vitamin D3, but also carcasses containing vitamin D3 and 25-hydroxy vitamin D3. The vitamin D3 content in adipose tissue from the UV-exposed minipigs was 150-260 ng/g and the content was 90-150 ng/g in the orally supplemented minipigs. In study 2, minipigs were UV-exposed daily for 49 days. Subsequently, one group (n=2) was fed a vitamin D-free diet and another group (n=2) was dosed daily with 13C-labeled vitamin D3. The concentrations of vitamin D3 and 25-hydroxy vitamin D3 in seru...Continue Reading

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Citations

Jan 23, 2016·Journal of Nutritional Science·Anders BurildJette Jakobsen
May 9, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Matthew D TeegardenSteven J Schwartz
Oct 26, 2016·The Proceedings of the Nutrition Society·Aoife Hayes, Kevin D Cashman
Jan 4, 2018·Nutrients·Jette JakobsenSusanne Bügel
Nov 15, 2017·PloS One·D Enette Larson-MeyerBrenda M Alexander
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Ieva MartinaityteRolf Jorde
Nov 14, 2019·Nutrients·D Enette Larson-MeyerTanya M Halliday
Oct 11, 2019·Current Developments in Nutrition·Jette JakobsenMichael Rychlik
Jul 23, 2021·Critical Reviews in Food Science and Nutrition·Holly R NeillL Kirsty Pourshahidi
Aug 11, 2021·Animal Science Journal = Nihon Chikusan Gakkaihō·Josiane C PanissonBruno A N Silva

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