Tissue Crowding Induces Caspase-Dependent Competition for Space

Current Biology : CB
Romain LevayerEduardo Moreno

Abstract

Regulation of tissue size requires fine tuning at the single-cell level of proliferation rate, cell volume, and cell death. Whereas the adjustment of proliferation and growth has been widely studied [1-5], the contribution of cell death and its adjustment to tissue-scale parameters have been so far much less explored. Recently, it was shown that epithelial cells could be eliminated by live-cell delamination in response to an increase of cell density [6]. Cell delamination was supposed to occur independently of caspase activation and was suggested to be based on a gradual and spontaneous disappearance of junctions in the delaminating cells [6]. Studying the elimination of cells in the midline region of the Drosophila pupal notum, we found that, contrary to what was suggested before, Caspase 3 activation precedes and is required for cell delamination. Yet, using particle image velocimetry, genetics, and laser-induced perturbations, we confirmed [6] that local tissue crowding is necessary and sufficient to drive cell elimination and that cell elimination is independent of known fitness-dependent competition pathways [7-9]. Accordingly, activation of the oncogene Ras in clones was sufficient to compress the neighboring tissue and e...Continue Reading

References

Feb 29, 2000·Cell·D A Prober, B A Edgar
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Martin-BlancoA Garcia-Bellido
Sep 5, 2002·Genes & Development·David A Prober, Bruce A Edgar
Jan 16, 2003·The Journal of Cell Biology·Kiwamu TakemotoMasayuki Miura
Apr 7, 2004·Cell·Claire de la CovaLaura A Johnston
Apr 7, 2004·Cell·Eduardo Moreno, Konrad Basler
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Boris I Shraiman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lars HufnagelBoris I Shraiman
Feb 8, 2008·Genesis : the Journal of Genetics and Development·Lilian MonteroPeter Gallant
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pierre-Luc BardetJean-Paul Vincent
Mar 17, 2010·Current Biology : CB·Nikolay NinovEnrique Martín-Blanco
Sep 14, 2010·Current Biology : CB·Magali SuzanneStéphane Noselli
Dec 20, 2011·PloS One·Andrea Maria PereiraEnrique Martin-Blanco
Jul 4, 2012·Seminars in Cell & Developmental Biology·Molly C Schroeder, Georg Halder
Jul 28, 2012·Current Opinion in Cell Biology·Andrea I McClatchey, Alpha S Yap
Jul 3, 2013·Current Biology : CB·Marisa M MerinoEduardo Moreno
Aug 15, 2013·Nature Reviews. Molecular Cell Biology·Jean-Paul VincentL Alberto Baena-Lopez
Feb 11, 2014·Current Opinion in Cell Biology·Morgan O'HayreJ Silvio Gutkind
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sebastian J StreichanLars Hufnagel
Nov 25, 2014·Biophysical Journal·Morgan DelarueGiovanni Cappello
Jan 21, 2015·Cell·Marisa M MerinoEduardo Moreno
Jan 22, 2015·Nature·Bruno MonierMagali Suzanne
Mar 11, 2015·Current Biology : CB·Eduardo MorenoChrista Rhiner

❮ Previous
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Citations

Apr 12, 2016·Communicative & Integrative Biology·Romain Levayer, Eduardo Moreno
Jun 21, 2016·Trends in Cell Biology·Marisa M MerinoEduardo Moreno
Oct 28, 2016·Mechanisms of Development·M C Diaz de la Loza, B J Thompson
Dec 22, 2016·International Journal of Molecular Sciences·Yuhei KawamotoErina Kuranaga
Mar 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sayaka SaitohYasuyuki Fujita
Mar 11, 2017·Scientific Reports·Ailijiang KadeerYasuyuki Fujita
Apr 2, 2017·The Journal of Cell Biology·Sérgio SimõesUlrich Tepass
Apr 14, 2017·Nature·Thuan Beng SawBenoit Ladoux
Apr 20, 2017·Genes·Simone Di GiacomoDaniela Grifoni
Jun 16, 2017·Molecular Biology of the Cell·Delany RodriguezAnthony W De Tomaso
Oct 27, 2017·BMC Biology·Gongping Sun, Denise J Montell
Aug 5, 2017·The Journal of Cell Biology·Gongping SunDenise J Montell
Aug 9, 2018·Annual Review of Cell and Developmental Biology·Swapna A GudipatyDenise J Montell
Apr 26, 2016·Nature Communications·Laura WagstaffEugenia Piddini
Nov 11, 2018·Development·Luis Alberto Baena-LopezReuben McGregor
Mar 16, 2019·Journal of Cell Science·Sergio Casas-Tintó, Alberto Ferrús
Jul 3, 2019·Journal of Cell Science·Dina S Coelho, Eduardo Moreno
Jan 15, 2020·Nature Reviews. Cancer·Medhavi Vishwakarma, Eugenia Piddini
May 12, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Katarzyna Kuzmicz-Kowalska, Anna Kicheva
Feb 15, 2018·Development·Georgina C FletcherBarry J Thompson
Jul 7, 2019·Development·Sarah BowlingTristan A Rodríguez
Dec 24, 2018·Physical Review Letters·John J Williamson, Guillaume Salbreux
Mar 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ojan Khatib Damavandi, David K Lubensky
Aug 12, 2020·Nature Reviews. Genetics·Nicholas E Baker
Sep 28, 2017·Physical Review. E·Shunsuke Yabunaka, Philippe Marcq
Oct 5, 2017·Scientific Reports·Simone Di GiacomoDaniela Grifoni
Jan 18, 2017·Computational and Mathematical Methods in Medicine·Flavien CaraguelAngélique Stéphanou
Jun 2, 2018·BioMed Research International·Derek Cui XuLuis Alberto Baena-Lopez
Jan 17, 2021·Nature Communications·Anh Phuong LeBenoît Ladoux
Nov 20, 2020·Nature·Rashmi PriyaDidier Y R Stainier
Jan 11, 2021·Molecular Biotechnology·Jaison JeevanandamMichael K Danquah
Feb 26, 2019·Biophysical Journal·Satoru OkudaKatsuhiko Sato
Dec 29, 2020·Current Biology : CB·Motoyuki OgawaHidenori Ichijo
Apr 26, 2020·Biophysical Journal·Satoru Okuda, Koichi Fujimoto
Mar 24, 2021·Developmental Biology·Mariana Marques-Reis, Eduardo Moreno
Mar 31, 2021·Briefings in Functional Genomics·Michail Paraskevopoulos, Alison P McGuigan

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Methods Mentioned

BETA
delamination

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