PMID: 11898390Mar 20, 2002Paper

Tissue culture models for studies of hormone and vitamin action in bone cells

Vitamins and Hormones
P V N Bodine, B S Komm

Abstract

Osteoporosis is a major health care concern and levies a serious financial burden on the world health care system. For this reason, many physicians and scientists are engaged in research to better understand and treat this disease. To this end, numerous in vitro bone cell models have been developed to explore the cellular and molecular mechanisms of skeletal biology and for the identification and characterization of new drug targets and therapies. In this chapter, we review many of these cellular models as tools to study the hormonal regulation of bone metabolism. In particular, we pay special attention to new human bone cell models, since these have the greatest relevance to osteoporosis research and drug discovery. These new models include (1) the use of peripheral blood mononuclear cells as progenitors of osteoclasts and primary cultures of mesenchymal stem cells as precursors of osteoblasts; (2) the development of conditionally immortalized preosteoclastic and osteoblastic cell lines using temperature-sensitive large T-antigens; and (3) the establishment of the first osteocytic cell lines. Thus, we now have at our disposal many good in vitro models to investigate the regulation of bone resorption and formation by hormones, ...Continue Reading

Citations

Apr 22, 2003·Journal of Cellular Biochemistry·J BilliardP V N Bodine
Mar 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J G MountJ S Price
Aug 8, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher K Hee, Steven B Nicoll
Sep 25, 2004·Molecular Endocrinology·Julia BilliardPeter V N Bodine
Sep 9, 2006·Reviews in Endocrine & Metabolic Disorders·Peter V N Bodine, Barry S Komm
Feb 15, 2011·Calcified Tissue International·Umut A GurkanOzan Akkus
Sep 9, 2005·Journal of Cellular Biochemistry·Peter V N BodineBarry S Komm
Sep 30, 2005·Journal of Anatomy·M ColittiJ S Price
Jan 24, 2008·Cell Research·Peter V N Bodine
Sep 20, 2008·Chemical Reviews·Adele L Boskey, Rani Roy
Aug 28, 2021·International Journal of Molecular Sciences·Stefano PulciniThelma A Pertinhez

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