Tissue detection of natural killer cells in colorectal adenocarcinoma

BMC Gastroenterology
Ioannis S PapanikolaouAthanasios Archimandritis

Abstract

Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the expression of CD16 and CD57 [immunohistochemical markers of natural NK cells] in colorectal adenocarcinoma. Presence of NK cells was investigated in 82 colorectal adenocarcinomas. Immunohistochemical analysis was performed, using 2 monoclonal antibodies (anti-Fc Gamma Receptor II, CD16 and an equivalent to Leu-7, specific for CD-57). The number of immunopositive cells (%) was evaluated by image analysis. The cases were characterized according to: patient gender and age, tumor location, size, grade, bowel wall invasion, lymph node metastases and Dukes' stage. NK cells were detected in 79/82 cases at the primary tumor site, 27/33 metastatic lymph nodes and 3/4 hepatic metastases; they were detected in levels similar to those reported in the literature, but their presence was not correlated to the clinical or pathological characteristics of the series, except for a negative association with the patients' age (p = 0.031). Our data do not support an association of NK cell tissue presence with clinical or pathological variables of...Continue Reading

References

Dec 1, 1996·The Australian and New Zealand Journal of Surgery·M V Agrez
Sep 1, 1997·Clinical Immunology and Immunopathology·K OgataT Nomura
Oct 6, 2001·Veterinary Immunology and Immunopathology·F ChianiniM Domingo
May 25, 2002·Cancer Investigation·Jeffrey S Miller
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Ioannis S PapanikolaouPanayiotis S Davaris

❮ Previous
Next ❯

Citations

Dec 20, 2012·Journal of Biomedicine & Biotechnology·Xavier CamousAnis Larbi
Oct 7, 2015·Current Colorectal Cancer Reports·Timothy J Zumwalt, Ajay Goel

❮ Previous
Next ❯

Software Mentioned

Sigma Scan Pro

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Immunity & Ageing : I & a
Łukasz HakAndrzej Myśliwski
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Xiang-yu ZhaoXiao-jun Huang
Archives of Gynecology and Obstetrics
Emel Ebru OzcimenFiliz Fatma Yanik
© 2021 Meta ULC. All rights reserved