Tissue disposition, excretion and metabolism of 2,2',4,4',6-pentabromodiphenyl ether (BDE-100) in male Sprague-Dawley rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
H HakkG Larsen

Abstract

The absorption, disposition, metabolism and excretion study of orally administered 2,2',4,4',6-pentabromodiphenyl ether (BDE-100) was studied in conventional and bile-duct cannulated male rats. In conventional rats, >70% of the radiolabelled oral dose was retained at 72 h, and lipophilic tissues were the preferred sites for disposition, i.e. adipose tissue, gastrointestinal tract, skin, liver and lungs. Urinary excretion of BDE-100 was very low (0.1% of the dose). Biliary excretion of BDE-100 was slightly greater than that observed in urine, i.e. 1.7% at 72 h, and glucuronidation of phenolic metabolites was suggested. Thiol metabolites were not observed in the bile as had been reported in other PBDE metabolism studies. Almost 20% of the dose in conventional male rats and over 26% in bile-duct cannulated rats was excreted in the faeces, mainly as the unmetabolized parent, although large amounts of non-extractable radiolabel were also observed. Extractable metabolites in faeces were characterized by mass spectrometry. Monohydroxylated pentabromodiphenyl ether metabolites were detected; mono- and di-hydroxylated metabolites with accompanying oxidative debromination were also observed as faecal metabolites. Tissue residues of [(14)...Continue Reading

References

Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G L LarsenE Klasson-Wehler
Apr 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E Klasson-WehlerI Brandt
Jan 1, 1995·Toxicology Letters·G A AnsariM F Khan
Apr 2, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·U Orn, E Klasson-Wehler
Jul 17, 1998·Nature·J de BoerJ P Boon
May 7, 1999·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K Hu, N J Bunce
May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J J DilibertoL S Birnbaum
Nov 14, 2001·Archives of Environmental Contamination and Toxicology·L HovanderE Klasson Wehler
Jun 18, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H HakkE Klasson-Wehler
Feb 21, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H HakkU Orn
Jun 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anna MorckEva Klasson Wehler
Jul 10, 2003·Environment International·Heldur Hakk, Robert J Letcher

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Citations

Nov 5, 2011·Environmental Science & Technology·Yongquan LaiZongwei Cai
Mar 21, 2013·Environmental Science & Technology·Jianteng SunGuibin Jiang
Apr 12, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yongquan LaiZongwei Cai
Feb 13, 2013·Environmental Toxicology and Chemistry·Crystal Y UsenkoSascha Usenko
Sep 2, 2009·Mass Spectrometry Reviews·Dongli Wang, Qing X Li
Dec 13, 2019·Toxicologic Pathology·June K DunnickArun Kumar R Pandiri
Oct 23, 2008·Environmental Science & Technology·Barry C KellyFrank A P C Gobas
Aug 5, 2010·Journal of Agricultural and Food Chemistry·Heldur HakkDrew Rutherford

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