Tissue Distribution and Residues of Antibiotics in Normal and Emergency - Slaughtered Dairy Cows After Intramammary Treatment

Journal of Food Protection
J F M Nouws, G Ziv

Abstract

Following intramammary infusion of normal cows with a single dry cow and four lactating-cow antibiotic formulations containing penicillin G, neomycin, dihydro-streptomycin, lincomycin and framycetin, low concentrations of drug residues were detected in the kidney, urine, and for some drugs, also in blood and the liver, during the first 24 h after treatment. Drug residues were not detected in meat. In emergency-slaughtered mastitic cows, drug levels were considerably higher and persisted for a longer period than in normal cows. Persistence of drug residues is discussed in terms of the rate and extent of drug absorption from the udder, differences between normal and diseased cows, and effect of dosage form.

Citations

Jul 30, 2020·Journal of Veterinary Pharmacology and Therapeutics·Peter LeesPierre-Louis Toutain
Mar 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·R Kroker
Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·J M EnsinkA G Vulto
Dec 18, 2014·Journal of the American Veterinary Medical Association·Lindsey W KissellGeof W Smith
Jun 16, 2016·Scientific Reports·Zhoumeng LinJim E Riviere
Jun 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·G ZivB Kurtz

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