Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water

Toxicology and Applied Pharmacology
Elaina M KenyonJanice W Yager

Abstract

The relationship of exposure and tissue concentration of parent chemical and metabolites over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite(s) rather than parent chemical alone. This is an issue for AsV because its trivalent metabolites have unique toxicities and relatively greater potency compared to their pentavalent counterparts for many endpoints. In this study, dose-dependency in tissue distribution and urinary excretion for inorganic arsenic and its methylated metabolites was assessed in female C57Bl/6 mice exposed to 0, 0.5, 2, 10 or 50 ppm arsenic (as arsenate, AsV) in their drinking water for 12 weeks. No adverse effects were observed and body weight gain did not differ significantly among groups. Urinary excretion of arsenite monomethylarsonous acid (MMA(III)), dimethylarsinous acid (DMA(III)), dimethylarsinic acid (DMAV), and trimethylarsine oxide (TMAO) increased linearly with dose, whereas AsV and monomethylarsonic acid (MMAV) excretion was non-linear with respect to dose. Total tissue arsenic accumulation was greatest in kidney > lung > urinary bladder > skin > blood > liver. Monomethyl arsenic (MMA, i.e. MMA(III)+MMAV) was the predominant metabolite in kidney, whereas dimeth...Continue Reading

Citations

Jun 13, 2014·Environmental Science and Pollution Research International·Wafa KharroubiRachid Sakly
Oct 6, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Joseph R McDermottZijuan Liu
Jun 20, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M A García-SevillanoJ L Gómez-Ariza
Oct 26, 2010·International Archives of Occupational and Environmental Health·David C DauphinéCraig Steinmaus
Jul 14, 2011·Environmental Health Perspectives·Karen D BradhamDavid J Thomas
Nov 12, 2013·Environmental Toxicology and Pharmacology·Elyssa R GelmannKathleen M McCarty
Jul 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frank BoellmannRussell S Thomas
Mar 10, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Masanao YokohiraSamuel M Cohen
Jul 29, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·H J ClewellJ W Yager
Nov 24, 2012·Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science·Anita K PatlollaJose A Centeno
Jun 16, 2010·Regulatory Toxicology and Pharmacology : RTP·Sean M HaysKannan Krishnan
Sep 16, 2009·Pharmacology, Biochemistry, and Behavior·Ebany J Martinez-FinleyAndrea M Allan
Aug 19, 2014·Journal of Applied Toxicology : JAT·Rogelio Recio-VegaCesar Gonzalez-De Alba
Aug 27, 2014·Journal of Biochemical and Molecular Toxicology·Adeola O AdebayoJoshua W Hamilton
Mar 4, 2014·Regulatory Toxicology and Pharmacology : RTP·Lesa L AylwardChristopher R Kirman
Sep 18, 2013·Critical Reviews in Toxicology·Samuel M CohenMichal Eldan
Sep 8, 2009·Environmental Research·Manuel Torres-AvilaMaria E Gonsebatt
May 11, 2011·Free Radical Biology & Medicine·Swaran J S Flora
Sep 27, 2014·The Science of the Total Environment·Jie ZhangHeqing Shen
Jan 11, 2017·Human & Experimental Toxicology·Wafa KharroubiGérard Lizard
Jun 21, 2011·Environmental Health Perspectives·J Christopher StatesR Clark Lantz
Sep 20, 2018·Journal of Toxicology and Environmental Health. Part a·Harvey J ClewellP Robinan Gentry
Sep 14, 2013·Journal of Toxicology and Environmental Health. Part a·Karen D BradhamDavid J Thomas
May 21, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Meytal ChernoffBrandon L Pierce
Oct 7, 2011·Metallomics : Integrated Biometal Science·Toby G Rossman, Catherine B Klein
Jan 5, 2021·Biological Trace Element Research·Maryam Dehdashti MoghadamZahra Moosavi
Feb 10, 2019·Neurotoxicology and Teratology·Christopher L MooreSherry A Ferguson

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