Tissue distribution and urinary excretion of essential elements in rats orally exposed to aluminum chloride

Biological Trace Element Research
J Chmielnicka, M Nasiadek

Abstract

The purpose of this study was to determine disorders in the metabolism of the essential elements (Ca, Fe, Cu, and Zn) in some tissues of rats, as well as to detect the dynamics of urinary excretion of these metals after oral administration of 20 mgAl/kg every day for 8 wk. The elements were determined in brain, kidneys, blood, and urine of the animals in 1st, 2nd, 3rd, 4th, and 8th wk after the exposure to AlCl3. After the 1st wk of aluminium administration, we observed increase of Ca and a decrease of Fe in blood. In brain Ca, Fe, and Cu concentrations were significantly higher in Al-treated rats than in controls after 8-wk exposure. The concentration changes of the essential metals in the tissue were accompanied by increase of the Ca, Fe, and Zn urinary excretion. We assume that the increase in urinary excretion of Ca and the decrease of Fe in the blood may be sensitive indicators of oral aluminium administration.

References

Dec 1, 1979·The Journal of Clinical Investigation·J Misiti, J L Spivak
Nov 1, 1979·Archives of Environmental Health·M AbdullaB Haeger-Aronsen
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Jan 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B FultonE H Jeffery
Nov 1, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Cochran, V Chawtur
Sep 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·P AllainY Mauras
Dec 1, 1987·Kidney International·T H IttelA C Alfrey
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J Fleming, J G Joshi
Jun 1, 1987·Scandinavian Journal of Gastroenterology·E M HaramA Berstad
Feb 22, 1968·The New England Journal of Medicine·M LotzF C Bartter
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Lione
Jun 18, 1983·British Medical Journal·J B CannataG S Fell
Jul 25, 1983·Life Sciences·G A Trapp
Jan 1, 1980·Annals of the New York Academy of Sciences·J T PennistonT Itano
Jun 1, 1983·Zeitschrift für Ernährungswissenschaft·E GrassmannJ J Kim
Dec 1, 1984·Biological Trace Element Research·M A Burnatowska-Hledin, G H Mayor

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Citations

Sep 1, 1994·Biological Trace Element Research·J ChmielnickaM Paradowski
Feb 1, 1994·Biological Trace Element Research·J ChmielnickaE Lewandowska-Zyndul
May 14, 2003·Ecotoxicology and Environmental Safety·Jadwiga Chmielnicka, Marzenna Nasiadek
Jan 1, 1997·Pharmacology & Toxicology·D J SánchezJ L Domingo
Jun 29, 2004·Archives of Toxicology·Stella T MahieuMaría Mónica Elías
Feb 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·M BoudeyD Bouglé

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