Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure

Reproductive Toxicology
Daniel BorgUlrika Bergström

Abstract

Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.

Citations

Jan 5, 2014·Environmental Science and Pollution Research International·Wendy D'HollanderLieven Bervoets
Sep 6, 2011·Reproductive Toxicology·Shu-Ching ChangJohn L Butenhoff
May 17, 2014·Critical Reviews in Toxicology·Robert G Ellis-HutchingsRichard Billington
Feb 19, 2017·Biochemical and Biophysical Research Communications·Christoffer Tamm, Sandra Ceccatelli
Dec 13, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Young LeeJongho Jeon
Nov 18, 2020·Environmental Toxicology and Chemistry·Amila O De SilvaElsie M Sunderland
Jan 22, 2014·Journal of Agricultural and Food Chemistry·Sara J LuptonJohn J Johnston

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