Tissue distribution of amphetamine isomers in a fatal overdose

Journal of Analytical Toxicology
E MeyerAndré P De Leenheer

Abstract

A young man (22 years old) died of a cardiorespiratory arrest a few hours following admission to the emergency department of a hospital. He was found lying seriously ill in the parking lot of a dance club. Screening of postmortem blood and urine with enzyme multiplied immunoassay (EMIT) detected only amphetamines, caffeine, and cotinine. Further screening of blood, urine, and stomach contents with thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) was negative for all three matrices. Specific conditions for amphetamines were used for the gas chromatographic (GC) screening (GC-mass spectrometric [MS] and GC-nitrogen-phosphorus detection). This resulted in the preliminary identification of amphetamine in both blood and urine. Confirmation of the presence of amphetamine in all available postmortem specimens was provided by mass and infrared spectral data (GC-MS and GC-Fourier transform infrared spectrometry) after derivatization. Quantitative results and differentiation between the enantiomers of amphetamine were obtained after chiral derivatization. The calculated concentrations disclosed amphetamine ingestion as the cause of this fatality.

Citations

Aug 12, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Migaku Kawaguchi, Akiko Takatsu
Jun 3, 2004·Forensic Science International : Synergy·F MusshoffB Madea
Jun 3, 2004·Forensic Science International : Synergy·Olaf H Drummer
Jan 23, 2019·Journal of Analytical Toxicology·Michael NedahlKristian Linnet
Jun 18, 2019·Drug Testing and Analysis·Raimo A Ketola, Pirkko Kriikku
Sep 18, 2012·The Journal of Physical Chemistry. a·Iwona Olejniczak, Katarzyna Pogorzelec-Glaser
Jun 29, 1999·Analytical Chemistry·T A BrettellR Saferstein

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