Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Hong LuCurtis Klaassen

Abstract

Concentrative nucleoside transporters (Cnts) and equilibrative nucleoside transporters (Ents) have essential physiological functions and are important in disposition of anticancer and antiviral nucleoside analogs. Information on tissue distribution of Cnts and Ents in rodents is sparse. Thus, the present study aimed to determine the distribution of Cnt1-3 and Ent1-3 transcripts in 19 tissues of Sprague-Dawley rats and C57BL/6 mice of both genders. These six transcripts were quantified using the branched DNA signal amplification assay. Cnt1 transcripts were highest in small intestine, followed by kidney and testes, with similar expression in both species. Cnt2 mRNA was expressed highest in the small intestine of both rats and mice, intermediate in liver of rats but not in mice, and lower in thymus and spleen of both species. Cnt3 mRNA has marked species differences, with the highest expression in lung of rats but uterus of mice. Ent1 mRNA was most highly expressed in testes and lung of both species. Ent1 mRNA was highly expressed in liver and pituitary of mice, but not in rats. Ent2 mRNA was highly expressed in testes and brain of both species. Ent3 mRNA was highest in kidney, followed by testes, in both species. Significant gen...Continue Reading

References

May 14, 1999·Molecular Medicine Today·S A BaldwinJ D Young
Jul 17, 1999·Brain Research. Molecular Brain Research·C M AndersonF E Parkinson
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V B Pai, M C Nahata
Feb 13, 2001·Biochemical and Biophysical Research Communications·M PennycookeI R Coe
Apr 3, 2001·Cardiovascular Research·P ChareonthaitaweeP G Camici
Nov 16, 2001·Trends in Cardiovascular Medicine·R D Lasley, E J Smart
Jun 5, 2002·Anti-cancer Drugs·Pnina FishmanIlan Cohn
Jan 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tyra M Leazer, Curtis D Klaassen
May 15, 2003·Journal of Physiology and Biochemistry·F J CasadoM Pastor-Anglada
May 29, 2003·Current Topics in Medicinal Chemistry·Jing LinSteven M Winter
May 30, 2003·The Journal of Endocrinology·D A ReesJ Ham
Jul 3, 2003·Pflügers Archiv : European journal of physiology·Stephen A BaldwinJames D Young
Jul 12, 2003·Pflügers Archiv : European journal of physiology·Jennifer H GrayKathleen M Giacomini
Oct 11, 2003·Pharmacology & Therapeutics·Stefania MerighiPier Andrea Borea
Oct 23, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Supratim ChoudhuriCurtis D Klaassen
Nov 25, 2003·Health & Social Care in the Community·Jane CallaghanPanos Vostanis

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Citations

Aug 29, 2007·Journal of Physiology and Biochemistry·M Pastor-AngladaF J Casado
Apr 12, 2008·Purinergic Signalling·Andreas DeussenAnnette Pexa
Dec 13, 2006·Nucleosides, Nucleotides & Nucleic Acids·Parween Abdulla, Imogen R Coe
Jul 5, 2008·Nucleosides, Nucleotides & Nucleic Acids·Míriam Molina-ArcasMarçal Pastor-Anglada
Jun 15, 2010·Nucleosides, Nucleotides & Nucleic Acids·M Molina-Arcas, M Pastor-Anglada
Aug 15, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xingguo Cheng, Curtis D Klaassen
Sep 2, 2010·The Journal of Pharmacology and Experimental Therapeutics·Maggie HamYasutada Akiba
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Apr 2, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kathryn GrahamCarol E Cass
Dec 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer B RoseImogen R Coe
Sep 4, 2013·Journal of Molecular Endocrinology·Keir Menzies, Johan Auwerx
Sep 25, 2009·World Journal of Gastroenterology : WJG·Jeff Huaqing Ye, Vazhaikkurichi M Rajendran
May 1, 2009·Future Medicinal Chemistry·Meryem Köse, Anke C Schiedel
Dec 8, 2005·Journal of Drug Targeting·Neil R MathiasVincent H L Lee
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Pastor-AngladaF J Casado
Mar 30, 2016·Pharmacology Research & Perspectives·Michael D NguyenB Jill Venton
Oct 5, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Melissa MarviImogen R Coe
Oct 14, 2008·Pharmacology & Therapeutics·Luca AntonioliCorrado Blandizzi
Jun 16, 2007·International Immunopharmacology·C EvaldssonS Uppugunduri
May 25, 2012·Synapse·Masahiro MishinaKiichi Ishiwata
Jul 11, 2006·International Journal of Cardiology·George P H LeungRicky Y K Man
Jun 14, 2006·Brain Research Reviews·Mehmet Cansev
Mar 7, 2006·Brain Research·Christina R ZamzowFiona E Parkinson
Aug 25, 2015·Journal of Pharmaceutical and Biomedical Analysis·Jueun LeeGeum-Sook Hwang
Jan 30, 2015·Acta Physiologica·D ThimmC E Müller
Nov 26, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hideaki NakamuraHiroshi Maeda
Sep 12, 2013·Current Opinion in Pharmacology·Seng Chuan TangAlfred H Schinkel
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Masuhiro Nishimura, Shinsaku Naito
Apr 7, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Zidong Donna FuCurtis D Klaassen
May 7, 2016·Annals of the New York Academy of Sciences·Missag H ParseghianRichard A Richieri
May 18, 2016·Advanced Drug Delivery Reviews·Camille AlamReina Bendayan
Jan 1, 2009·Annual Review of Marine Science·Keith C Hester, Peter G Brewer
Oct 18, 2016·Scientific Reports·Laura CasasXabier Irigoien

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