PMID: 8939014Nov 11, 1996Paper

Tissue distribution of DDVP after fatal ingestion

Forensic Science International : Synergy
K ShimizuM Sakata

Abstract

Tissue distribution of dichlorvos (DDVP) was determined in a case of fatal ingestion using a rapid and simple gas chromatographic (GC) assay. Remarkable autopsy findings were congestion of the lung and kidneys and bleeding ulcer extending from the dorsum of the tongue to the upper pharynx. The serum cholinesterase activity was 2 IU/1, however, miosis was not observed. In the stomach, 250 ml of volatile fluid was found. Tissue distribution of DDVP was determined using a newly developed simple and rapid GC method. DDVP was found in the spleen and heart at higher concentrations (3340 and 815 micrograms/g, respectively), and also detected in the urine at the lowest level (4.5 micrograms/ml). The DDVP concentrations in blood, brain, lung, kidney and liver were 29, 9.7, 81, 80 and 20 micrograms/ml or g, respectively.

References

Mar 1, 1966·Toxicology and Applied Pharmacology·E R Laws

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Citations

Jun 29, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·R HeinigG J Krol
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mario Vincenzo RussoPasquale Avino
Apr 7, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Swaran J S Flora
Jun 13, 2008·Journal of Forensic Sciences·Emuri AbeJean-Claude Alvarez
Apr 16, 1998·Journal of Toxicology. Clinical Toxicology·H SenoO Suzuki
Jun 3, 2004·Forensic Science International : Synergy·F MusshoffB Madea
Mar 31, 2018·Journal of Forensic Sciences·Akina NaraTetsuya Takagi

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