Tissue distribution of drug-metabolizing enzymes in humans

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
G M PacificiG B Muraro


1. The activities of the ethoxycoumarin O-deethylase (ECOD), epoxide hydrolase (EH), UDP-glucuronyl transferase (GT), glutathione S-transferase (GST), acetyl transferase (AT) and sulphotransferase (ST) were measured in 6 liver, 8 lung, 8 kidney, 8 intestinal mucosa and 22 urinary bladder mucosa specimens from human subjects. EH and GT were studied with styrene oxide and 1-naphthol, respectively, as substrates, GST, AT and ST were studied with benzo(a)pyrene-4,5-oxide, p-aminobenzoic acid and 2-naphthol, respectively. 2. The enzyme activities were detectable at significant rates in liver, lungs, kidneys and gut. In urinary bladder, EH, GT, GST and ST only were detectable. The liver catalyzed the various reactions at higher rates than did other tissues. 3. Of the extrahepatic tissues, the intestinal mucosa contained the highest activities of AT (50% of liver) and ST (30% of liver), whereas kidneys contained the highest activity of GT (50% of liver) and GST (80% of liver). GST was the enzyme with the widest tissue distribution.


Dec 18, 1978·European Journal of Clinical Pharmacology·K W BockD Josting
May 1, 1979·Analytical Biochemistry·R D SekuraW B Jakoby
Nov 10, 1975·Biochimica Et Biophysica Acta·B R Sonawane, G W Lucier
Jan 1, 1986·Pharmacology·G M PacificiA Rane
Jan 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A Aitio
Jul 1, 1981·Clinical Pharmacokinetics·C F George
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·A J BaarsD D Breimer
Jan 1, 1980·Annals of the New York Academy of Sciences·R E McMahon
Jun 1, 1984·Biochemical Pharmacology·W L WhyteA R Buckpitt
Feb 11, 1980·Life Sciences·M E McManusD S Davies
Feb 1, 1982·Acta Pharmacologica Et Toxicologica·G M Pacifici, A Rane
May 1, 1982·Acta Pharmacologica Et Toxicologica·S W JakobssonR A Prough
Feb 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M PacificiD S Davies
Jan 1, 1981·Pharmacology·H MukhtarD D Breimer

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Jan 1, 1993·Archives of Toxicology·A L MendralaR J Nolan
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·T WalleG R Pesola
Jan 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·M Láznícek, A Láznícková
Jan 15, 1991·Biochemical Pharmacology·P G GervasiF Ursino
Jan 1, 1992·Pharmacology & Therapeutics·F P Guengerich
Jan 1, 1994·Pharmacology & Therapeutics·M S O'Mahony, K W Woodhouse
Jun 6, 2000·Advanced Drug Delivery Reviews·D D ShenK E Thummel
Dec 12, 2001·Toxicology Letters·Johannes G FilserGyörgy A Csanády
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Mar 1, 1996·British Journal of Clinical Pharmacology·E A EatonT Walle
May 5, 1999·Fundamental & Clinical Pharmacology·L BartheG Houin
Nov 1, 1995·British Journal of Pharmacology·J VergésP du Souich
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Jun 3, 2000·Annual Review of Pharmacology and Toxicology·R H Tukey, C P Strassburg
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·J H Lin, A Y Lu
Feb 26, 2011·The European Respiratory Journal·M W ButlerR G Crystal
Nov 1, 1992·Environmental Health Perspectives·F F KadlubarN P Lang
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Jan 27, 2004·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H M KorashyA O S El-Kadi
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