PMID: 6166278Jan 1, 1981Paper

Tissue distribution of human interferons after exogenous administration in rabbits, monkeys, and mice

Archives of Virology
A BilliauP de Somer

Abstract

Preparations of human leukocyte (alpha) and fibroblast (beta) interferon were given intramuscularly to rabbits and monkeys, and circulating interferon was measured. In rabbits, but not in monkeys, a marked difference between the two interferons was noted in that higher titers of circulating antiviral activity were obtained with leukocyte than with fibroblast interferon. In mice, injected interperitoneally, a similar difference could be noted. However, levels of antiviral activity in homogenates of spleens and lungs did not differ between mice injected with either interferon. Fibroblast interferon that was injected intrathecally in monkeys was found to diffuse throughout the cerebrospinal canal and to reach the serum compartment. Some interferon could also be recovered from the pia mater surrounding the brain hemispheres, but none was found in the deeper layers of the brain.

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Citations

Jan 1, 1993·Cancer Chemotherapy and Pharmacology·A Bonetti, S Kim
Jan 1, 1981·Archives of Virology·A Billiau
Feb 9, 1996·Deutsche medizinische Wochenschrift·C Rabe, A Holstege
Feb 1, 1992·Physiology & Behavior·L S Crnic, M A Segall
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
Aug 1, 1986·Antiviral Research·V Ramamurthy, W R Fleischmann
Sep 1, 1990·Brain, Behavior, and Immunity·M A Segall, L S Crnic
Apr 16, 2004·Behavioural Brain Research·Amanda Kwant, Boris Sakic
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Margaret F Bennewitz, W Mark Saltzman
Apr 1, 1986·Journal of Interferon Research·P G HigginsD A Tyrrell
Jul 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M Pardridge
Feb 26, 2011·Fluids and Barriers of the CNS·William M Pardridge
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Mar 30, 2016·Expert Opinion on Drug Delivery·William M Pardridge
Oct 17, 2008·Physiological Reviews·Bente K Pedersen, Mark A Febbraio
Jan 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Rikke Krogh-MadsenBente Klarlund Pedersen
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen C Land, Froogh Darakhshan
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G M Scott
Dec 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L A Toth
Feb 6, 2021·International Journal of Pharmaceutics·Manisha ChoudhariSunil Kumar Dubey

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