PMID: 9527645Apr 4, 1998Paper

Tissue distribution of sex steroids: concentration of 17beta-oestradiol and cyproterone acetate in selected organs of female Wistar rats

Pharmacology & Toxicology
F SchleicherW Schunack

Abstract

The tissue distribution of 17beta-oestradiol and cyproterone acetate was investigated after intravenous and intragastric administration to female Wistar rats by measuring the time course of the concentration of the sex steroids in plasma, liver, kidney, brain, and heart by radioimmunoassay. Test substances were administered intravenously in doses of 0.1 mg/kg each and intragastrically in doses of 10 mg/kg (17beta-oestradiol) and 0.1 mg/kg (cyproterone acetate) corresponding to the expected oral bioavailability. Tissue distribution was assessed within each mode of administration by AUCorgan/AUCplasma-quotients (Q-values), and between both routes of administration by F-values representing (bio- and organ availability) and R-values, which express the organ load after intragastric compared to intravenous administration if the same amount of drug has been made bioavailable in the plasma after both routes (for explanation see next page). The absolute bioavailability of 17beta-oestradiol after intragastric administration of 10 mg/kg was ca. 8%. The oestradiol liver load after intragastric administration was about 20 times higher than after intravenous administration, whereas the drug load of other organs was independent of the adminis...Continue Reading

Citations

Dec 5, 2002·Mutation Research·Giovanni Brambilla, Antonietta Martelli
Jun 24, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huiqing ChenHyunyoung Jeong
Jul 29, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Heike LindenmaierJohanna Weiss
Dec 22, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H JeongJ H Fischer

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