Tissue distribution of tetrabromobisphenol A and cadmium in mixture inhalation exposure

Toxicology and Industrial Health
Jiangfei ChenChangjiang Huang

Abstract

Tetrabromobisphenol A (TBBPA) and cadmium chloride (CdCl2) are the typical representative pollutants of brominated flame retardants and heavy metals found in the air of e-waste recycling workshops. However, their metabolic kinetics through mixture inhalation is unknown. In the present study, 8-week old Institute of Cancer Research (ICR) male mice were whole-body exposed to TBBPA and CdCl2 mixtures by inhalation. Tissue samples were collected for TBBPA and cadmium (Cd) analysis at 2, 4, 6, and 8 weeks during exposure and at 4 and 8 weeks after the completion of the 8-week exposure period. TBBPA was mainly distributed to the lungs, liver, kidney, testis, and spleen, with a high amount accumulated in the brain, liver, and spleen. Cd was mainly distributed to the lungs, liver, and kidney, with a high amount accumulated in the liver, kidney, and testis and a low amount accumulated in brain and serum. Tissue burden of TBBPA and Cd in all organs increased in a dose- and time-dependent manner during the exposure period. However, 4 weeks after the completion of an 8-week exposure, TBBPA concentrations in the liver, testis, brain, and serum and Cd concentrations in the liver, testis, and kidney were higher than the corresponding tissue c...Continue Reading

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Citations

Jun 4, 2020·International Journal of Molecular Sciences·Jayant Patwa, Swaran Jeet Singh Flora
Mar 30, 2021·Ecotoxicology and Environmental Safety·Jiangfei ChenChangjiang Huang

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Methods Mentioned

BETA
chip

Software Mentioned

SPSS

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