Tissue distribution of trichloroethylene and its metabolites in a forensic case

Journal of Analytical Toxicology
S De BaereA De Leenheer

Abstract

A fatality that was due to the ingestion of the halogenated solvent trichloroethylene is presented. The decedent was a 43-year-old male who was found dead at his home. Screening of the blood and stomach contents with the enzyme multiplied immunoassay technique and radioimmunoassay demonstrated the presence of ethanol, amphetamine-like compounds, caffeine, cotinine, and acetaminophen. These compounds were present in toxicologically irrelevant concentrations as confirmed by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography (GC). The Fujiwara reaction was performed on all available matrices, and it revealed the presence of chlorinated hydrocarbons in high concentrations. A specific GC method with electron capture detection allowed the quantitation of trichloroethylene and its metabolites trichloroethanol and trichloroacetic acid in different matrices. GC with Fourier-transform infrared detection was used for the confirmation of the identity of trichloroethylene.

Citations

Feb 18, 2011·Biotechnology Letters·Kaushik Dey, Pranab Roy
Oct 12, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·S Muralidhara, J V Bruckner
Jul 15, 2015·Journal of Forensic and Legal Medicine·Ugo Da BroiLorenzo Desinan
Jun 3, 2004·Forensic Science International : Synergy·F MusshoffB Madea
Jun 3, 2004·Forensic Science International : Synergy·Sarah M R Wille, Willy E E Lambert
Jun 29, 1999·Analytical Chemistry·T A BrettellR Saferstein

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