Tissue Doppler image-derived measurements during isovolumic contraction predict exercise capacity in patients with reduced left ventricular ejection fraction

JACC. Cardiovascular Imaging
Eun Joo ChoPartho P Sengupta

Abstract

We explored the incremental value of quantification of tissue Doppler (TD) velocity during the brief isovolumic contraction (IVC) phase of the cardiac cycle for the prediction of exercise performance in patients referred for cardiopulmonary exercise testing (CPET). Experimental studies have shown that rapid left ventricular (LV) shape change during IVC is essential for optimal onset of LV ejection. However, the incremental value of measuring IVC velocities in clinical settings remains unclear. A total of 82 subjects (age 53+/-14 years, 56 men) were studied with echocardiography and CPET. Reduced LV ejection fraction (EF) (EF<50%) was present in 38 (46%) subjects. Pulsed-wave annular TD velocities were averaged from the LV lateral and septal annulus during isovolumic contraction (IVCa), ejection, isovolumic relaxation, and early and late diastole (Aa) and compared with peak oxygen consumption (VO2) and percentage of the predicted peak VO2 (% predicted peak VO2) obtained from CPET. Patients with reduced EF had lower IVCa (6.3 vs. 4.5 cm/s, p=0.04), ejection (7.7 vs. 5.5 cm/s, p<0.001), and Aa velocities (7.9 vs. 6.6 cm/s, p=0.04). Similarly, % predicted peak VO2 was lower in patients with reduced EF (52.9% vs. 73.1%, p<0.001) and...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jan 1, 1983·The American Journal of Cardiology·M B HigginbothamF R Cobb
Sep 16, 1999·The New England Journal of Medicine·W G Stevenson, L W Stevenson
May 12, 2000·Journal of the American College of Cardiology·J S GottdienerR C Boineau
Feb 18, 2004·Circulation·Stanislaw J Skaluba, Sheldon E Litwin
May 4, 2004·Journal of the American College of Cardiology·Alison M DuncanMichael Y Henein
Jul 28, 2004·Journal of Molecular and Cellular Cardiology·Donald M Bers
Jul 29, 2005·Proceedings. Biological Sciences·John O Dabiri, Morteza Gharib
Dec 2, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ross ArenaMary Ann Peberdy
Jan 10, 2006·Clinical Physiology and Functional Imaging·Per LindqvistElsadig Kazzam
Feb 1, 2006·The Journal of General Physiology·Kenneth B Campbell, Murali Chandra
Feb 1, 2006·The Journal of General Physiology·Julian E StelzerRichard L Moss
Sep 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philippe DiolezJean-Michel Franconi
Jul 5, 2008·Heart Failure Clinics·Partho P SenguptaMarek Belohlavek
Jan 22, 2009·JAMA : the Journal of the American Medical Association·Jasmine GrewalPatricia A Pellikka

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Citations

Apr 17, 2013·European Heart Journal Cardiovascular Imaging·Haruhiko AbePartho P Sengupta
Jul 24, 2015·European Journal of Clinical Investigation·Edoardo SciattiMarco Metra
Feb 23, 2017·Journal of Cardiovascular Medicine·Elena ZambonGianfranco Sinagra
May 15, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Jacob T CaldwellJudy M Muller-Delp

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