PMID: 11337315May 19, 2001Paper

Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens

Urology
L S MarksV E Tyler

Abstract

To determine the effects of a saw palmetto herbal blend (SPHB) compared with finasteride on prostatic tissue androgen levels and to evaluate needle biopsies as a source of tissue for such determinations. Prostate levels of testosterone and dihydrotestosterone (DHT) were measured on 5 to 10-mg biopsy specimens (18-gauge needle cores) in three groups of men with symptomatic benign prostatic hyperplasia: 15 men receiving chronic finasteride therapy versus 7 untreated controls; 4 men undergoing prostate adenomectomy to determine sampling variability (10 specimens each); and 40 men participating in a 6-month randomized trial of SPHB versus placebo, before and after treatment. Prostatic tissue DHT levels were found to be several times higher than the levels of testosterone (5.01 versus 1.51 ng/g), that ratio becoming reversed (1.05 versus 3.63 ng/g) with chronic finasteride therapy. The finasteride effect was statistically significant for both androgens (P <0.01), and little overlap of individual values between finasteride-treated and control patients was seen. In the randomized trial, tissue DHT levels were reduced by 32% from 6.49 to 4.40 ng/g in the SPHB group (P <0.005), with no significant change in the placebo group. For contro...Continue Reading

References

Aug 1, 1975·Endocrinology·J A ReskoH L Stadelman
Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Jan 1, 1988·American Journal of Clinical Oncology·E BruunC Frimodt-Møller
May 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J A ReskoA E Huhl

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Citations

Jan 31, 2004·Urology·Armand ZiniKeith Jarvi
Feb 20, 2004·Urology·Albaha BarqawiE David Crawford
Jun 7, 2002·The Journal of Urology·Andrew H FeiferLaurence Klotz
Feb 14, 2002·Australian Family Physician
Feb 10, 2006·The New England Journal of Medicine·Robert S DiPaola, Ronald A Morton
Mar 22, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Lynn S AdamsDavid Heber
Sep 4, 2004·The American Journal of Chinese Medicine·Edward M Gong, Glenn S Gerber
Nov 6, 2013·Annual Review of Medicine·Goutham VemanaStephen J Freedland
Jan 11, 2014·Asian Journal of Andrology·Lori A Cooper, Stephanie T Page
Dec 26, 2001·Current Opinion in Urology·Franklin C Lowe, Elliot Fagelman
Feb 20, 2016·Journal of Pain and Symptom Management·Gwen K WyattJames Herman
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Jean-Pierre Raynaud
May 27, 2008·Urology·Leonard S MarksPeter S Nelson
Sep 1, 2012·Journal of the Science of Food and Agriculture·Giuseppe ProcidaMarina Zacchigna
Nov 7, 2007·The Urologic Clinics of North America·Mohit Khera, Larry I Lipshultz
Sep 13, 2006·Nutrition and Cancer·Raven M Bonnar-PizzornoEmily White
Jan 11, 2018·Endocrine-related Cancer·Clovis Boibessot, Paul Toren
Aug 3, 2006·The Journal of Clinical Endocrinology and Metabolism·Stephanie T PageWilliam J Bremner
Nov 9, 2002·Experimental Biology and Medicine·Craig W HadleySteven K Clinton
May 18, 2020·Journal of the American Academy of Dermatology·James T PathoulasRonda S Farah

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