Tissue-engineered biological dressing accelerates skin wound healing in mice via formation of provisional connective tissue

Histology and Histopathology
Elina S ChermnykhEkaterina A Vorotelyak

Abstract

Despite recent advances in bioengineered therapies, wound healing remains a serious clinical problem. In acute full-thickness wounds, it is desirable to replace both the damaged dermis and epidermis in a single procedure. This approach requires appropriate properties of tissue-engineered dressings to support simultaneous regenerative processes in the dermis and epidermis while they are temporally separated in the natural wound healing process. In this study, a collagen-based scaffold inhabited by skin cells was employed. Its ability to stimulate the skin repair of full-thickness excisional splinting wounds in a murine model was evaluated in comparison with that of acellular collagen and commercially available gelatin porous sponge Spongostan®. The study showed that cell-based skin equivalent promoted the immediate filling of the wound bed and provided simultaneous reorganization of the dermal component into highly vascularized granulation-like tissue and rapid epithelialization, thus improving the quality of healing. Inflammation was delayed and less pronounced. In contrast, acellular collagen and especially Spongostan® failed to demonstrate similar results. The porous structure of Spongostan® prevented effective long-term epit...Continue Reading

Citations

Jun 21, 2019·Cells·Alexandra L RippaEkaterina A Vorotelyak
Mar 7, 2021·International Journal of Molecular Sciences·Arkadii K BeilinNadya G Gurskaya
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Simon C de GrootMargriet A Huisman
May 1, 2021·International Journal of Molecular Sciences·Nadezhda A EvtushenkoNadya G Gurskaya

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