Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives

Advanced Healthcare Materials
Cédryck VaquetteSaso Ivanovski

Abstract

The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo-spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of their regenerative potential and limitations. The review also elaborates on the future of periodontal tissue engineering, including scaffold customization for individual periodontal defects, TEC's functionalization strategies ...Continue Reading

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Citations

Jan 10, 2019·Journal of Clinical Periodontology·Mark BartoldSaso Ivanovski
Sep 8, 2019·International Journal of Molecular Sciences·Chan Ho Park
Feb 26, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bin GuoXiaohui Rausch-Fan
Jul 19, 2020·Journal of Clinical Medicine·Dobrila NesicIrena Sailer
Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
Jul 20, 2019·Micromachines·Owen TaoSimon D Tran
Oct 3, 2020·Scientific Reports·Yao YaoWilliam V Giannobile
Mar 7, 2020·Journal of Periodontal Research·Reuben J StaplesCedryck Vaquette
Oct 28, 2020·Tissue Engineering. Part a·David FraserDanielle S W Benoit
Dec 12, 2020·International Journal of Molecular Sciences·Min Guk Kim, Chan Ho Park
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola d'AvanzoMassimo Fresta
Apr 22, 2021·ACS Biomaterials Science & Engineering·Greeshma RatheeshCedryck Vaquette
May 1, 2021·International Journal of Molecular Sciences·Kexin JiaoPingping Han
May 6, 2021·Antioxidants·Mohamed MekhemarChristof Dörfer
Jul 13, 2021·World Journal of Stem Cells·Aline QueirozMarinella Holzhausen
Aug 24, 2021·Frontiers in Bioengineering and Biotechnology·Jessica M LatimerWilliam V Giannobile

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