Tissue engineered vascular grafts for pediatric cardiac surgery

Translational Pediatrics
Toshihiro Shoji, Toshiharu Shinoka

Abstract

New technologies and science have contributed to improved surgical outcomes in patients with congenital cardiovascular diseases. However, current materials display shortcomings, such as risk of infection and lack of growth capacity when applied to the pediatric patient population. Tissue engineering has the potential to address these limitations as the ideal tissue engineered vascular graft (TEVG) would be durable, biocompatible, nonthrombogenic, and ultimately remodel into native tissue. The traditional TEVG paradigm consists of a scaffold, cell source, and the integration of the scaffold and cells via seeding. The subsequent remodeling process is driven by cellular adhesion and proliferation, as well as, biochemical and mechanical signaling. Clinical trials have displayed encouraging results, but graft stenosis is observed as a frequent complication. Recent investigations have suggested that a host's immune response plays a vital role in neotissue formation. Current and future studies will focus on modulating host immunity as a means of reducing the incidence of stenosis.

Citations

Dec 7, 2018·Hernia : the Journal of Hernias and Abdominal Wall Surgery·T TerazawaY Nakayama
Feb 6, 2020·Experimental and Therapeutic Medicine·Jingjing LvHuiwen Chen
Oct 10, 2020·Science·Laura E Niklason, Jeffrey H Lawson
Apr 4, 2021·Micromachines·Laszlo Kiraly, Sanjairaj Vijayavenkataraman
Aug 25, 2021·Expert Opinion on Biological Therapy·Ryuma IwakiToshiharu Shinoka
Oct 7, 2021·Biomechanics and Modeling in Mechanobiology·Cansu KarakayaSandra Loerakker

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