Tissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial Aesthetics

The Journal of Craniofacial Surgery
Mimi R BorrelliHermann Peter Lorenz

Abstract

The craniofacial region is anatomically complex and is of critical functional and cosmetic importance, making reconstruction challenging. The limitations of current surgical options highlight the importance of developing new strategies to restore the form, function, and esthetics of missing or damaged soft tissue and skeletal tissue in the face and cranium. Regenerative medicine (RM) is an expanding field which combines the principles of tissue engineering (TE) and self-healing in the regeneration of cells, tissues, and organs, to restore their impaired function. RM offers many advantages over current treatments as tissue can be engineered for specific defects, using an unlimited supply of bioengineered resources, and does not require immunosuppression. In the craniofacial region, TE and RM are being increasingly used in preclinical and clinical studies to reconstruct bone, cartilage, soft tissue, nerves, and blood vessels. This review outlines the current progress that has been made toward the engineering of these tissues for craniofacial reconstruction and facial esthetics.

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Citations

Oct 21, 2020·Journal of Clinical Medicine·Jeremie D OliverMichael S Hu
Jan 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaohang ChenXing Wang
Feb 1, 2021·Cancer Treatment and Research Communications·Azam Bozorgi, Leila Sabouri
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Oct 3, 2021·Journal of Tissue Engineering and Regenerative Medicine·Ariel HirschhornGideon Rechavi

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