PMID: 11324271Apr 28, 2001Paper

Tissue engineering in periodontics using rhBMP-2

Journal of the New Zealand Society of Periodontology
M J Danesh-Meyer

Abstract

The results of these studies show that rhBMP-2 clearly enhances regeneration in periodontal defects (Figures 2&3). The extent of regeneration appears to be significantly influenced by the nature of the carrier material used to deliver the rhBMP-2 to the periodontal wound. While the positive effects of rhBMP-2 on osteogenesis are well established, less is known about the way in which rhBMP-2 effects cementogenesis, or its role in the formation of a new periodontal ligament. From the studies reviewed, it would appear that rhBMP-2 facilitate in the formation of cellular cementum on previously denuded root surfaces. This newly formed cementum has also been shown to support an organised periodontal ligament attachment. Mechanisms related to the possible role of rhBMP-2 in ankylosis are presently unclear and will require further investigation as such sequelle may complicate the clinical utility of rhBMP-2 in periodontal regeneration. Root resorption has also been reported in the above mentioned studies and appears to be related to the concentration of rhBMP-2. Further research directed at understanding how different carriers influence the way in which the rhBMP-2 is released during wound healing should assist researchers with how to ...Continue Reading

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