Tissue engineering toward organ-specific regeneration and disease modeling

MRS Communications
Christian MandryckyYing Zheng

Abstract

Tissue engineering has been recognized as a translational approach to replace damaged tissue or whole organs. Engineering tissue, however, faces an outstanding knowledge gap in the challenge to fully recapitulate complex organ-specific features. Major components, such as cells, matrix, and architecture, must each be carefully controlled to engineer tissue-specific structure and function that mimics what is found in vivo. Here we review different methods to engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for organ transplantation in the USA. We highlight advances in tissue engineering approaches to enable the regeneration of complex tissue and organ substitutes, and provide tissue-specific models for drug testing and disease modeling. We discuss the current challenges and future perspectives toward engineering human tissue models.

References

Jan 1, 1983·The Anatomical Record·R E Bulger, D C Dobyan
Jan 1, 1982·Canadian Journal of Physiology and Pharmacology·B KoreckyK Rakusan
Sep 1, 1994·Journal of Applied Physiology·R R MercerJ D Crapo
Jan 1, 1996·Toxicologic Pathology·E WisseA Vermoesen
Dec 30, 1999·Biomaterials·R S KaneG M Whitesides
Feb 9, 2000·American Journal of Physiology. Renal Physiology·H Pavenstädt
Jun 1, 1964·The Journal of Cell Biology·E R WEIBEL, B W KNIGHT
Nov 13, 2003·Electrophoresis·Samuel K Sia, George M Whitesides
Oct 27, 2004·Journal of Thoracic Imaging·Harumi ItohHiroto Hatabu
Apr 5, 2005·Toxicologic Pathology·David E MalarkeyRobert R Maronpot
Jul 1, 2005·Analytical Chemistry·Jonathan W SongShuichi Takayama
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ali KhademhosseiniJoseph P Vacanti
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Linda G Griffith, Melody A Swartz
Mar 7, 2006·Nature Reviews. Drug Discovery·Petra S Dittrich, Andreas Manz
Mar 28, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mladen J KocicaFrancisco Torrent-Guasp
Apr 8, 2006·Microvascular Research·Kenneth M ChrobakJoe Tien
Apr 22, 2006·Nature Methods·Dirk R AlbrechtSangeeta N Bhatia
Apr 25, 2006·Lancet·Anthony AtalaAlan B Retik
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Dec 6, 2006·Biomedical Microdevices·Ali KhademhosseiniMilica Radisic
Feb 3, 2007·Lab on a Chip·Yo TanakaTakehiko Kitamori
Feb 23, 2007·Nature·Sheila MacNeil
Mar 29, 2007·Analytical Chemistry·Bor-han ChuehShuichi Takayama
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elliot E Hui, Sangeeta N Bhatia
Apr 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C MageeA B Leichtman
May 24, 2007·Tissue Engineering·Antonios G MikosGordana Vunjak-Novakovic
Mar 13, 2008·Tissue Engineering. Part a·Eun Jung LeeKevin D Costa
Feb 24, 2009·Journal of Tissue Engineering and Regenerative Medicine·Rohin K IyerMilica Radisic
Mar 7, 2009·Tissue Engineering. Part a·Rohini GuptaMichael V Sefton
Oct 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John B West
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Deok-Ho KimAndre Levchenko
Feb 17, 2010·Tissue Engineering. Part a·Karina H NakayamaAlice F Tarantal
Mar 6, 2010·Nature Protocols·Dong QinGeorge M Whitesides
Jun 26, 2010·Science·Thomas H PetersenLaura E Niklason
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Jul 16, 2010·Nature Medicine·Harald C OttJoseph P Vacanti
Oct 1, 2010·Advanced Materials·Brandon V SlaughterNicholas A Peppas
Dec 3, 2010·American Journal of Physiology. Renal Physiology·David P BasileTimothy A Sutton

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Citations

May 1, 2020·Advanced Healthcare Materials·Xiaolin CuiTim Woodfield
Nov 6, 2018·Nanotechnology·Dawn S Y LinBoyang Zhang
Jan 12, 2019·Tissue Engineering. Part B, Reviews·Nicole HauptmannKlaus Liefeith
Jan 30, 2020·International Journal of Molecular Sciences·Silvia BarbonAndrea Porzionato
Nov 7, 2019·Journal of Biomaterials Applications·Mengying XieChan Chen
Oct 13, 2020·Journal of Tissue Engineering and Regenerative Medicine·Nima ZakeriMehran Solati-Hashjin
Dec 22, 2020·Journal of Biomaterials Applications·Abhishek IndurkarPrajakta Dandekar
Jan 21, 2021·International Journal of Molecular Sciences·Georgia PennarossaTiziana A L Brevini
Apr 23, 2021·Xenotransplantation·Joseph Sushil RaoChristopher Burlak
Jun 18, 2021·Advanced Healthcare Materials·Mian WangYu Shrike Zhang
Jul 17, 2021·International Journal of Biological Macromolecules·Murugan Prasathkumar, Subramaniam Sadhasivam
Dec 29, 2021·Frontiers of Medicine·Chuanqi LiuYuanyuan Zhang

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