Tissue expression of 165-aa vascular permeability factor after spinal cord injury is not influenced by dexamethasone administration in rats

Neuroscience Letters
Jesús Vaquero, Mercedes Zurita

Abstract

Using immunohistochemistry, RT-PCR, and Western Blot techniques, we studied the tissue expression of the 165-aa Vascular permeability factor (VPF) after spinal cord injury (SCI) in adult Wistar rats. The results were compared according to that the animals received or non-dexamethasone, at the dose of 1mg/kg and day after trauma. Furthermore, the different functional recovery between treated and non-treated animals was recorded. Although the administration of dexamethasone showed a beneficial effect on the functional recovery of the animals, the tissue expression of VPF after SCI is not influenced by dexamethasone administration. Therefore, the neuroprotective effect of the dexamethasone after experimental SCI is not mediated through an interference on the biological effects of the 165-aa vascular permeability factor.

References

Jan 1, 1992·Journal of Neurosurgery·E D Hall
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Apr 1, 1984·Journal of Neurosurgery·A I FadenM T Smith
Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·S NagD W Kilty
Apr 13, 1999·Journal of Neurosurgery·J VaqueroS Coca
Jan 25, 2002·Journal of Neurosurgery·Mercedes ZuritaCarmen Morales
Aug 15, 2002·Neuropathology and Applied Neurobiology·Jesús VaqueroSantiago Oya

❮ Previous
Next ❯

Citations

Nov 25, 2005·Journal of Neurosurgery·Marsha J Merrill, Edward H Oldfield
Nov 30, 2004·Neuroscience Letters·Manoel Baldoino Leal FilhoKonradin Metze
Nov 12, 2014·Frontiers in Cellular Neuroscience·Vasil MecollariJoost Verhaagen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.