Tissue expression of the mulibrey nanism-associated Trim37 protein in embryonic and adult mouse tissues

Histochemistry and Cell Biology
Jukka KallijärviAnna-Elina Lehesjoki

Abstract

Mutations in the TRIM37 gene underlie mulibrey nanism (muscle-liver-brain-eye nanism), a rare monogenic developmental disorder characterized by severe growth failure, characteristic dysmorphic features, cardiopathy, failure of sexual maturation, and metabolic syndrome. The TRIM37 protein, a member of the tripartite motif subfamily of RING finger proteins, is highly conserved between human and mouse. High evolutionary conservation is seen also at the gene level. We here show that the mouse Trim37 gene presents several alternative splice variants, including a testis-specific transcript with an additional 3' exon. By Northern blot analysis the highest level of Trim37 mRNA was detected in testis and brain. In embryonic tissues, the Trim37 protein was detected in epithelia, including ducts of the developing pancreas, epithelium of the midgut and nasal epithelium. In adult mouse tissues, Trim37 immunoreactivity was detected in the central and peripheral nervous systems, including enteric ganglia, retina, and the adrenal medulla. Moreover, specific cellular populations in the adenohypophysis, pancreatic islets, intestine and gonads showed intense Trim37 staining. Both nuclear and granular cytoplasmic staining patterns were observed. T...Continue Reading

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Citations

Dec 7, 2006·Histochemistry and Cell Biology·Douglas J TaatjesJürgen Roth
Nov 1, 2007·Histochemistry and Cell Biology·Christian ZuberJürgen Roth
Mar 31, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Susann KarlbergRalf Butzow
Apr 1, 2009·The Journal of Pathology·Niklas KarlbergHannu Jalanko
Dec 10, 2013·The Journal of General Virology·Azah A TabahLouis M Mansky
Jun 4, 2016·American Journal of Medical Genetics. Part a·Enza MozzilloAdriana Franzese
Dec 24, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·L HusovaT Brychta

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