Tissue factor associates with survival and regulates tumour progression in osteosarcoma

Thrombosis and Haemostasis
Chris TiekenHenri H Versteeg

Abstract

Osteosarcoma is the most common primary malignant bone tumour. Patients often develop lung metastasis and have a poor prognosis despite extensive chemotherapy and surgical resections. Tissue Factor is associated with poor clinical outcome in a wide range of cancer types, and promotes angiogenesis and metastasis. The role of Tissue Factor in OS tumourigenesis is unknown. Fifty-three osteosarcoma pre-treatment biopsies and four osteosarcoma cell lines were evaluated for Tissue Factor expression, and a possible association with clinical parameters was investigated. Tissue Factor function was inhibited in an osteosarcoma cell line (143B) by shRNA knockdown or specific antibodies, and pro-tumourigenic gene expression, proliferation, matrigel invasion and transwell migration was examined. 143B cells were implanted in mice in the presence of Tissue Factor-blocking antibodies, and tumour volume, micro-vessel density and metastases in the lung were evaluated. Tissue Factor was highly expressed in 73.6 % of osteosarcoma biopsies, and expression associated significantly with disease-free survival. Tissue Factor was expressed in all four investigated cell lines. Tissue Factor was knocked down in 143B cells, which led to reduced expression ...Continue Reading

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Citations

Jun 28, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masanori SaitoHirotaka Haro
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Jul 22, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Weifeng XuXiaobing Chen

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