Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
M D Bravo-HerreraF Perez-Jimenez

Abstract

Mediterranean and high carbohydrate diets play a dominant role in the prevention of atherosclerosis as a result of their lipid lowering effect. However, diets can also have a protective effect in other ways, such as modulating tissue factor expression in circulating monocytes. Forty-one subjects participated in this randomised crossover study consisting of three dietary periods: a saturated fat enriched diet (SFA), a low fat and high carbohydrate diet (CHO), and a Mediterranean diet. Plasma levels of total cholesterol, triglycerides, low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were determined at the end of each dietary period, as was the expression of tissue factor (TF) in circulating monocytes isolated from blood samples. Total cholesterol, LDL-C, HDL-C and TF expression were lower after the Mediterranean and high carbohydrate diets than after the SFA diet, and there was a positive correlation between LDL-C levels and monocyte TF expression. High carbohydrate and Mediterranean diets reduce the expression of TF in circulating monocytes.

Citations

Nov 30, 2014·Endocrinology and Metabolism Clinics of North America·Chesney K RichterPenny M Kris-Etherton
Aug 15, 2014·Critical Reviews in Food Science and Nutrition·Javier Delgado-ListaJose Lopez-Miranda
Mar 12, 2011·Journal of the American College of Cardiology·Christina-Maria KastoriniDemosthenes B Panagiotakos
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Neil A SmartNigel Kwok
Sep 21, 2007·Molecular Nutrition & Food Research·Jose Lopez-MirandaCarmen Marin
Mar 24, 2007·Public Health Nutrition·Francisco Pérez-JiménezJosé López-Miranda
Mar 15, 2019·Biotechnology and Applied Biochemistry·Garshasb RigiGholamreza Ahmadian
Apr 4, 2017·Cardiovascular Therapeutics·Su-Jie JiaMing Zhao
Mar 15, 2006·Nutrition Reviews·Lluís Serra-MajemRamón Estruch
Nov 30, 2018·European Journal of Clinical Nutrition·Elena M Yubero-SerranoJose Lopez-Miranda

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