Tissue factor/tissue factor pathway inhibitor system and long-term prognosis after acute myocardial infarction

International Journal of Cardiology
V RoldánF Sogorb

Abstract

The tissue factor and tissue factor pathway inhibitor (TFPI) system has been studied in the acute phase of coronary disease but its prognostic importance has been less well assessed. We evaluated its association with recurrent coronary events during long-term follow-up after a myocardial infarction. We studied 55 consecutive patients with the following criteria for inclusion: (1) first myocardial infarct; (2) aged < 70 years; (3) non-complicated infarct; (4) low risk effort-test. Blood samples were taken 60-80 days after infarction. Tissue factor, total and free-TFPI were measured. A 4-year follow-up was carried out. Death, unstable angina and new myocardial infarction were considered as poor prognosis. There were no statistical differences in tissue factor/TFPI levels between patients and controls. Total-TFPI showed statistical correlation with total cholesterol (r = 0.59), triglycerides (r = 0.34), LDL-cholesterol (r = 40) and Lipoprotein(a) (r = 0.48). Patients with high levels of cholesterol, LDL-cholesterol and triglycerides showed elevated levels of total-TFPI with no differences in free-TFPI. During follow-up, 8 patients showed poor prognosis. There were no statistical associations between tissue factor/TFPI levels and p...Continue Reading

References

Jun 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J Fareed, J L Francis
Jan 1, 1995·British Heart Journal·E W LeathamA J Camm
Aug 1, 1996·The American Journal of Cardiology·H SoejimaN Aoyama
Sep 15, 1996·Circulation·J D MarmurM B Taubman
Oct 1, 1996·Haemostasis·P M Sandset
Aug 1, 1997·American Heart Journal·H SuefujiS Nakamura
Feb 14, 1998·The American Journal of Cardiology·K MisumiS Nakamura
Jun 22, 1999·Lancet·V FusterJ J Badimon
Jul 17, 1999·Atherosclerosis·E TremoliS Colli
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D ArdissinoP M Mannucci
Jun 3, 2000·The New England Journal of Medicine·D R Davis

❮ Previous
Next ❯

Citations

May 11, 2010·The Journal of Surgical Research·Rong JiangJakob Vinten-Johansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.