Tissue healing during degradation of a long-lasting bioresorbable gamma-ray-sterilised poly(lactic acid) mesh in the rat: a 12-month study

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Renaud de TayracPierre Mares

Abstract

The purpose was to evaluate soft-tissue healing after poly(lactic acid) (PLA(94)) mesh implantation in a rat model. Full-thickness abdominal wall defects were created in 108 Wistar rats, and reconstructed with 83 PLA(94) and 25 lightweight polypropylene (PPL) meshes. The meshes were previously gamma-ray sterilised with 25, 75 or 125 kGy to accelerate PLA(94) degradation. The inflammatory response in PLA(94) was significantly less pronounced and collagen organisation significantly better than in PPL. The higher the level of gamma-radiation, the higher the incidence of abdominal wall herniation (22.2, 31.3 and 52.6% with 25, 75 and 125 kGy, respectively). No herniation occurred in the PPL group. Tensile strength was dramatically reduced after gamma-ray-sterilised PLA(94) mesh implantation. The gamma-ray-sterilised PLA(94) mesh was poor in preventing abdominal wall hernia recurrences in a rat model.

Citations

May 25, 2016·International Urogynecology Journal·Michelle KellyNeil McGuire
Mar 25, 2014·Expert Review of Medical Devices·Luis M DelgadoDimitrios I Zeugolis
Nov 22, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vincent LetouzeyDavid O Callaghan
Nov 13, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Eoin MacCraithNiall F Davis

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