Tissue hydration in kidneys during preservation: a relaxometric analysis of time-dependent differences between cortex and medulla

Transplant International : Official Journal of the European Society for Organ Transplantation
J A van der HoevenRutger J Ploeg

Abstract

Cold preservation of donor organs induces hypothermia-related tissue edema as a result of a reduced activity of the ATP-dependent sodium pump at low temperatures. Hypothermia-induced tissue edema occurs in kidney preservation and is a significant risk factor for delayed graft function (DGF) after transplantation. DGF remains a major problem in kidney transplantation and is significantly associated with preservation injury. The state of hydration of cold-stored organs can be assessed from a biopsy for determination of the wet/dry weight ratio. As a non-invasive method to determine tissue hydration MRI T1 and T2 relaxometry can be used. In this study we have compared changes in tissue hydration in UW-preserved porcine kidneys with increasing cold ischemia times (CIT) using wet/dry weight ratio and MR ralaxometry. The results of the two techniques were correlated to evaluate the use of MR relaxometry. Wet/dry weight ratios of the renal cortex decreased with prolonged CIT (P < 0.01) whereas those of the medulla did not change significantly. T1 values of the cortex decreased with prolonged CIT (P < 0.01). T2 values of the cortex showed a non-significant decline with increased CIT. No significant changes in T1 and T2 were found in th...Continue Reading

Citations

Mar 13, 2003·Kidney International·Nicholas R BrookMichael L Nicholson
Apr 28, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Lionel BadetXavier Martin

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