PMID: 15377896Sep 21, 2004Paper

Tissue hypoxia activates JNK in the liver during hemorrhagic shock

Shock
Carol A McCloskeyT R Billiar

Abstract

The earliest signaling pathways responsible for initiating the systemic response to hemorrhagic shock (HS) remain poorly characterized. We have investigated the involvement of the mitogen-activated protein (MAP) kinase C-JUN N-terminal kinase (JNK) and its activation in the liver as an early response to tissue hypoxia soon after the initiation of hemorrhage. In the present studies, hemorrhage of mice to 25 mmHg for 30 min resulted in a significant (2.1-fold) increase in JNK phosphorylation within the liver. Results were similar in rats hemorrhaged to 40 mmHg for 1 h. Hypoxia alone, replicated by warm isolated hepatic ischemia in vivo or hepatocytes cultured under 1% oxygen, also resulted in JNK phosphorylation. Finally, preservation of tissue perfusion and oxygenation by pretreatment with a blood-soluble drag-reducing polymer (DRP) in the rat HS model prevented phosphorylation of JNK in the liver. These results identify tissue hypoxia as a key factor in activating early signaling events in the liver following hemorrhage, as measured by JNK phosphorylation.

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Citations

Sep 1, 2011·The Journal of Biological Chemistry·Ashish BhattacharjeeMartha K Cathcart
Jul 25, 2008·The Journal of Biological Chemistry·Ling WangLuo Lu
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Jul 25, 2008·Shock·Antonella CotoiaRussell L Delude
Feb 18, 2010·Shock·Heena P Santry, Hasan B Alam
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mallikarjuna R MetukuriRuben Zamora
Jun 16, 2011·Journal of Visualized Experiments : JoVE·Lauryn K KohutTimothy R Billiar
Jun 6, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jon CardinalAllan Tsung
Mar 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary W NaceAllan Tsung
May 12, 2005·Journal of Hepatology·Tetsuya UeharaDavid A Brenner
Jun 6, 2015·Canadian Journal of Physiology and Pharmacology·Qiang LiZhen Dong
May 30, 2012·Journal of Hepatology·Lee M OcuinRonald P DeMatteo
May 2, 2017·Shock·Tao ZhangToshishige Shibamoto
Mar 31, 2006·American Journal of Physiology. Cell Physiology·Björn M ThobeIrshad H Chaudry
Jun 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kathleen G RamanMitchell P Fink
Feb 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jun-Te HsuIrshad H Chaudry
Jan 18, 2008·American Journal of Physiology. Cell Physiology·Takashi KawasakiIrshad H Chaudry
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Jan 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Allan TsungDavid A Geller
Jun 10, 2016·The Journal of Biological Chemistry·Ling WangLuo Lu

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